Variant alleles of VEGF and risk of esophageal cancer and lymph node metastasis. (May 2014)
- Record Type:
- Journal Article
- Title:
- Variant alleles of VEGF and risk of esophageal cancer and lymph node metastasis. (May 2014)
- Main Title:
- Variant alleles of VEGF and risk of esophageal cancer and lymph node metastasis
- Authors:
- Gu, Haiyong
Qiu, Wanshan
Shi, Yijun
Chen, Suocheng
Yin, Jun - Abstract:
- <abstract> <title>Abstract</title> <p>Condensed abstract: The variant alleles of the functional polymorphisms, <italic>VEGF</italic> −2578 C &gt; A, −1498 T &gt; C and +936 C &gt; T, were not associated with risk of esophageal cancer and lymph node metastasis. Compared with the most common haplotype, C<sub>−2578</sub>T<sub>−1498</sub>C<sub>+936</sub>, the A<sub>−2578</sub>C<sub>−1498</sub>C<sub>+936</sub> haplotype was associated with a borderline significantly increased risk of esophageal cancer. C<sub>−2578</sub>C<sub>−1498</sub>C<sub>+936</sub> and A<sub>−2578</sub>T<sub>−1498</sub>T<sub>+936</sub> haplotypes were associated with significantly increased risk of esophageal cancer.</p> <p>Vascular endothelial growth factor (VEGF) is a potent stimulator for angiogenesis. It has been implicated in the growth and metastasis of esophageal cancer. Three functional single nucleotide polymorphisms (SNPs) of <italic>VEGF</italic> (−2578 C &gt; A, −1498 T &gt; C and +936 C &gt; T) are known to be related to VEGF expression. We conducted a case–control study to evaluate the effects of these three functional SNPs on the development of esophageal cancer and lymph node metastasis. A total of 497 cases and 380 controls were analyzed. Genotypes were determined by matrix assisted laser desorption/ionization time-of-flight mass spectrometry and direct sequence methods. The variant alleles of the functional polymorphisms <italic>VEGF</italic> −2578 C &gt; A, −1498 T &gt; C and +936 C &gt; T<abstract> <title>Abstract</title> <p>Condensed abstract: The variant alleles of the functional polymorphisms, <italic>VEGF</italic> −2578 C &gt; A, −1498 T &gt; C and +936 C &gt; T, were not associated with risk of esophageal cancer and lymph node metastasis. Compared with the most common haplotype, C<sub>−2578</sub>T<sub>−1498</sub>C<sub>+936</sub>, the A<sub>−2578</sub>C<sub>−1498</sub>C<sub>+936</sub> haplotype was associated with a borderline significantly increased risk of esophageal cancer. C<sub>−2578</sub>C<sub>−1498</sub>C<sub>+936</sub> and A<sub>−2578</sub>T<sub>−1498</sub>T<sub>+936</sub> haplotypes were associated with significantly increased risk of esophageal cancer.</p> <p>Vascular endothelial growth factor (VEGF) is a potent stimulator for angiogenesis. It has been implicated in the growth and metastasis of esophageal cancer. Three functional single nucleotide polymorphisms (SNPs) of <italic>VEGF</italic> (−2578 C &gt; A, −1498 T &gt; C and +936 C &gt; T) are known to be related to VEGF expression. We conducted a case–control study to evaluate the effects of these three functional SNPs on the development of esophageal cancer and lymph node metastasis. A total of 497 cases and 380 controls were analyzed. Genotypes were determined by matrix assisted laser desorption/ionization time-of-flight mass spectrometry and direct sequence methods. The variant alleles of the functional polymorphisms <italic>VEGF</italic> −2578 C &gt; A, −1498 T &gt; C and +936 C &gt; T SNPs were not associated with esophageal cancer risk. These <italic>VEGF</italic> genotypes were not associated with the risk of esophageal cancer after stratification. Furthermore, no association was observed between <italic>VEGF</italic> −2578 C &gt; A, −1498 T &gt; C and +936 C &gt; T polymorphisms and lymph node metastasis. Compared with the most common haplotype C<sub>−2578</sub>T<sub>−1498</sub>C<sub>+936</sub>, the A<sub>−2578</sub>C<sub>−1498</sub>C<sub>+936</sub> haplotype was associated with a borderline significantly increased risk of esophageal cancer. C<sub>−2578</sub>C<sub>−1498</sub>C<sub>+936</sub> and A<sub>−2578</sub>T<sub>−1498</sub>T<sub>+936</sub> haplotypes were associated with significantly increased risk of esophageal cancer. Variants in the functional polymorphisms of <italic>VEGF</italic> may not contribute to esophageal cancer and lymph node metastasis susceptibility. <italic>VEGF</italic> A<sub>−2578</sub>C<sub>−1498</sub>C<sub>+936, </sub> C<sub>−2578</sub>C<sub>−1498</sub>C<sub>+936</sub> and A<sub>−2578</sub>T<sub>−1498</sub>T<sub>+936</sub> haplotypes may be associated with increased risk of esophageal cancer. However, our results were obtained with a limited sample size and therefore this is a preliminary conclusion. Validation by a larger study with more diverse ethnic populations is needed.</p> </abstract> … (more)
- Is Part Of:
- Biomarkers. Volume 19:Number 3(2014)
- Journal:
- Biomarkers
- Issue:
- Volume 19:Number 3(2014)
- Issue Display:
- Volume 19, Issue 3 (2014)
- Year:
- 2014
- Volume:
- 19
- Issue:
- 3
- Issue Sort Value:
- 2014-0019-0003-0000
- Page Start:
- 252
- Page End:
- 258
- Publication Date:
- 2014-05
- Subjects:
- Biochemical markers -- Periodicals
610.28 - Journal URLs:
- http://informahealthcare.com/journal/bmk ↗
http://informahealthcare.com ↗
http://www.tandf.co.uk/journals/alphalist.html ↗ - DOI:
- 10.3109/1354750X.2014.902997 ↗
- Languages:
- English
- ISSNs:
- 1354-750X
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 2087.704500
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 3886.xml