Applications of surface-enhanced Raman scattering in advanced bio-medical technologies and diagnostics*. (May 2014)

• Record Type: Journal Article
• Authors: Nima, Zeid A.; Biswas, Abhijit; Bayer, Ilker S.; Hardcastle, Franklin D.; Perry, Donald; Ghosh, Anindya; Dervishi, Enkeleda; Biris, Alexandru S.
• Is Part Of: Drug metabolism reviews. Volume 46:Number 2(2014:Apr.)
• Page Start: 155
• Page End: 175
• Publication Date: 2014-05
• Subjects: Drugs -- Metabolism -- Periodicals; Pharmacokinetics -- Periodicals; Pharmaceutical Preparations -- metabolism -- Periodicals; 615
• DOI: 10.3109/03602532.2013.873451
• Languages: English
• ISSNs: 0360-2532

Abstract

<abstract> <title>Abstract</title> <p>In this review of the literature on surface-enhanced Raman scattering (SERS), we describe recent developments of this technique in the medical field. SERS has developed rapidly in the last few years as a result of the fascinating advancements in instrumentation and the ability to interpret complex Raman data using high-processional, computer-aided programs. This technique, has many advantages over ordinary spectroscopic analytical techniques – such as extremely high sensitivity, molecular selectivity, intense signal and great precision – that can be leveraged to address complex medical diagnostics problems. This review focuses on the SERS-active substrate, as well as major advances in cancer and bacteria detection and imaging. Finally, we present a perspective on anticipated future advancements in SERS techniques to address some of the most critical challenges in the areas of diagnostics, detection, and sensing.</p> </abstract>