Evaluation of Oxidative Stress Markers in Aqueous Humor of Primary Open Angle Glaucoma and Primary Angle Closure Glaucoma Patients. (August 2014)

• Record Type: Journal Article
• Authors: Goyal, Amita; Srivastava, Arpna; Sihota, Ramanjit; Kaur, Jasbir
• Is Part Of: Current eye research. Volume 39:Number 8(2014:Aug.)
• Page Start: 823
• Page End: 829
• Publication Date: 2014-08
• Subjects: Ophthalmology -- Periodicals; Eye -- Diseases -- Periodicals; Ophthalmology -- Periodicals; 573.88
• DOI: 10.3109/02713683.2011.556299
• Languages: English
• ISSNs: 0271-3683

Abstract

<abstract> <title>Abstract</title> <p> <italic>Purpose</italic>: The present study was designed to determine the levels of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and non-enzymatic antioxidants (vitamins C and E) in aqueous humor of primary open angle glaucoma (POAG) and primary angle closure glaucoma (PACG) patients.</p> <p> <italic>Materials and Methods</italic>: In this study, aqueous humor of POAG (<italic>n</italic> = 30) and PACG (<italic>n</italic> = 30) patients was obtained. For control, aqueous humor of 30 age-matched cataract patients (<italic>n</italic> = 30) was collected. Activities of antioxidant enzymes and non-enzymatic antioxidants levels were measured spectrophotometrically.</p> <p> <italic>Results</italic>: A significant increase in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities was found in aqueous humor of POAG and PACG patients as compared to cataract patients (<italic>p</italic> < 0.001). No significant changes were observed in catalase activity. The levels of vitamins C and E were significantly lower in the aqueous humor of POAG and PACG as compared to cataract patients (<italic>p</italic> < 0.001).</p> <p> <italic>Conclusion</italic>: These results suggest that a significant increase in oxidative stress may play a role in the pathogenesis of POAG and PACG. Determination of oxidative stress in aqueous humor may help in understanding the course of this disease, and oxidative damage might be a relevant target for both prevention and therapy.</p> </abstract>