NPM1, FLT3-ITD, CEBPA, and c-kit mutations in 312 Chinese patients with de novo acute myeloid leukemia. Issue 6 (September 2014)

• Record Type: Journal Article
• Authors: Su, Long; Gao, Su Jun; Li, Wei; Tan, Ye Hui; Cui, Jiu Wei; Hu, Rui Ping
• Is Part Of: Hematology. Volume 19:Issue 6(2014)
• Page Start: 324
• Page End: 328
• Publication Date: 2014-09
• Subjects: Blood -- Diseases -- Periodicals; Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; 616.15005
• DOI: 10.1179/1607845413Y.0000000132
• Languages: English
• ISSNs: 1024-5332

Abstract

<abstract> <title> <x content-type="archive" xml:space="preserve">Abstract</x> </title> <sec> <title>Objectives</title> <p>To explore <italic>NPM1</italic>, <italic>FLT3-</italic>ITD, <italic>CEBPA</italic>, and <italic>c-kit</italic> mutations in patients with acute myeloid leukemia (AML) from Chinese population.</p> </sec> <sec> <title>Methods</title> <p>In this study, we retrospectively analyzed the prevalence and clinical profile of <italic>NPM1</italic>, <italic>FLT3-</italic>ITD, <italic>CEBPA</italic>, and <italic>c-kit</italic> mutations in 312 patients with <italic>de novo</italic> AML.</p> </sec> <sec> <title>Results</title> <p>The frequencies of <italic>NPM1</italic>, <italic>FLT3-</italic>ITD, <italic>c-kit</italic>, and <italic>CEBPA</italic> mutations were 15.4, 14.0, 7.64, and 25.6%, respectively. The occurrence rate of <italic>NPM1</italic> mutations increased with age in patients younger than 60 years. <italic>NPM1</italic>, <italic>c-kit</italic>, and <italic>CEBPA</italic> mutations were all associated with French-American-British subtypes. Patients with <italic>NPM1</italic> mutations and <italic>FLT3</italic>-ITD presented with higher peripheral white blood cell counts and marrow blast percentages.</p> </sec> <sec> <title>Conclusion</title> <p>Both this and previous studies may suggest low frequencies of <italic>NPM1</italic> and <italic>FLT3</italic>-ITD mutations in AML patients from the Chinese population, and they may have a synergistic function in stimulating proliferation of leukemia cells.</p> </sec> </abstract>