A Transit Compartment Model Unmasks OxyContin's Reflective Pharmacokinetics From Urine Measurements in Humans. (1st June 2014)

• Record Type: Journal Article
• Authors: Linares, Oscar A.; Schiesser, William E.; Linares, Annemarie Daly; Stefanovski, Darko; Boston, Raymond C.
• Is Part Of: Journal of pain & palliative care pharmacotherapy. Volume 28:Number 2(2014)
• Page Start: 96
• Page End: 108
• Publication Date: 2014-06-01
• Subjects: Pain -- Treatment -- Periodicals; Analgesia -- Periodicals; Palliative treatment -- Periodicals; Analgesics -- Therapeutic use -- Periodicals; Pain -- drug therapy -- Periodicals; Pain -- prevention & control -- Periodicals; Palliative Care -- Periodicals; Analgesics -- therapeutic use -- Periodicals; 616.994
• DOI: 10.3109/15360288.2014.908991
• Languages: English
• ISSNs: 1536-0288

Abstract

<abstract> <title>ABSTRACT</title> <p>The absorption pattern of orally administered OxyContin (OXC) reflected in urine indicates that its appearance into systemic circulation undergoes transit absorption delays. The authors developed an OXC transit-delay compartment model that identified a new source of oxycodone hydrochloride (OC): the rate of appearance of OC due to OXC tablet dissolution in transit through the gastrointestinal (GI) tract (<italic>R</italic>^GI_a), which is due to disintegration of OXC's AcroContin delivery system. <italic>R</italic>^GI_a is independent of the biphasic dissolution and release of OC from the delivery system. The authors conclude that an OXC transit-delay compartment model can be of value in the interpretation of OXC pharmacokinetics.</p> </abstract>