EEG‐confirmed epileptic activity in a cat with VGKC‐complex/LGI1 antibody‐associated limbic encephalitis. Issue 1 (March 2014)

• Record Type: Journal Article
• Authors: Pakozdy, Akos; Glantschnigg, Ursula; Leschnik, Michael; Hechinger, Harald; Moloney, Teresa; Lang, Bethan; Halasz, Peter; Vincent, Angela
• Is Part Of: Epileptic disorders. Volume 16:Issue 1(2014:Mar.)
• Page Start: 116
• Page End: 120
• Publication Date: 2014-03
• Subjects: Epilepsy -- Periodicals; 616.853
• DOI: 10.1684/epd.2014.0635
• Languages: English
• ISSNs: 1294-9361

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>A 5‐year‐old, female client‐owned cat presented with acute onset of focal epileptic seizures with orofacial twitching and behavioural changes. Magnetic resonance imaging showed bilateral temporal lobe hyperintensities and the EEG was consistent with ictal epileptic seizure activity. After antiepileptic and additional corticosteroid treatment, the cat recovered and by 10 months of follow‐up was seizure‐free without any problem. Retrospectively, antibodies to LGI1, a component of the voltage‐gated potassium channel‐complex, were identified. Feline focal seizures with orofacial involvement have been increasingly recognised in client‐owned cats, and autoimmune limbic encephalitis was recently suggested as a possible aetiology. This is the first report of EEG, MRI and long‐term follow‐up of this condition in cats which is similar to human limbic encephalitis.</p> </abstract>