Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer. (16th May 2014)

• Record Type: Journal Article
• Authors: Zecchini, Vincent; Madhu, Basetti; Russell, Roslin; Pértega‐Gomes, Nelma; Warren, Anne; Gaude, Edoardo; Borlido, Joana; Stark, Rory; Ireland‐Zecchini, Heather; Rao, Roheet; Scott, Helen; Boren, Joan; Massie, Charlie; Asim, Mohammad; Brindle, Kevin; Griffiths, John; Frezza, Christian; Neal, David E; Mills, Ian G
• Is Part Of: EMBO journal. Volume 33:Number 12(2014)
• Page Start: 1365
• Page End: 1382
• Publication Date: 2014-05-16
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.201386874
• Languages: English
• ISSNs: 0261-4189

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="embj201386874-abs-0003"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Global chromatin occupancy‐ and gene expression data, together with 'pseudohypoxic' regulation of HIF1alpha stability establish a predominantly metabolic function of nuclear ARRB1 in prostate cancer. <boxed-text content-type="graphic" id="embj201386874-blkfxd-0002" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pghwghq27s" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>