Association of the variants in the BUD13‐ZNF259 genes and the risk of hyperlipidaemia. Issue 7 (30th April 2014)

• Record Type: Journal Article
• Authors: Aung, Lynn Htet Htet; Yin, Rui‐Xing; Wu, Dong‐Feng; Wang, Wei; Liu, Cheng‐Wu; Pan, Shang‐Ling
• Is Part Of: Journal of cellular and molecular medicine. Volume 18:Issue 7(2014)
• Page Start: 1417
• Page End: 1428
• Publication Date: 2014-04-30
• Subjects: Cytology; Medicine; Molecular Biology; Cytologie -- Périodiques; Médecine -- Périodiques; Biologie moléculaire -- Périodiques; Cytology -- Periodicals; Medicine -- Periodicals; Molecular biology -- Periodicals; 611.01805
• DOI: 10.1111/jcmm.12291
• Languages: English
• ISSNs: 1582-1838

Abstract

<abstract abstract-type="main" id="jcmm12291-abs-0001"> <title>Abstract</title> <p>The single nucleotide polymorphisms (SNPs) in the BUD13 homolog (BUD13) and zinc finger protein 259 (ZNF259) genes have been associated with one or more serum lipid traits in the European populations. However, little is known about such association in the Chinese populations. Our objectives were to determine the association of the <italic>BUD13</italic>/<italic>ZNF259 </italic>SNPs and their haplotypes with hypercholesterolaemia (HCH)/hypertriglyceridaemia (HTG) and to identify the possible gene–gene interactions among these SNPs. Genotyping of 6 SNPs was performed in 634 hyperlipidaemic and 547 normolipidaemic participants. The <italic>ZNF259</italic> rs2075290, <italic>ZNF259</italic> rs964184 and <italic>BUD13</italic> rs10790162 SNPs were significantly associated with serum lipid levels in both HCH and non‐HCH populations (<italic>P</italic> < 0.008–0.001). On single locus analysis, only <italic>BUD13</italic> rs10790162 was associated with HCH (OR: 2.23, 95% CI: 1.05, 4.75, <italic>P</italic> = 0.015). The G‐G‐A‐A‐C‐C haplotype, carrying rs964184‐G‐allele, was associated with increased risk of HCH (OR: 1.35, 95% CI: 1.10, 1.66, <italic>P</italic> = 0.005) and HTG (OR: 1.75, 95% CI: 1.39, 2.21, <italic>P</italic> <italic>=</italic> 0.000). The A‐C‐G‐G‐C‐C and A‐C‐A‐G‐T‐C haplotypes, carrying rs964184‐C‐allele, were associated with reduced risk of HCH (OR: 0.77, 95% CI: 0.61, 0.99, <italic>P</italic> = 0.039 and OR: 0.66, 95% CI: 0.47, 0.94, <italic>P</italic> <italic>=</italic> 0.021 respectively). On multifactor dimensionality reduction analyses, the two‐ to three‐locus models showed a significant association with HCH and HTG (<italic>P</italic> < 0.01–0.001). The <italic>BUD13/ZNF259 </italic>SNPs, which were significant in the European populations, are also replicable in the Southern Chinese population. Moreover, inter‐locus interactions may exist among these SNPs. However, further functional studies are required to clarify how these SNPs and genes actually affect the serum lipid levels.</p> </abstract>