Association between aggregative adherence fimbriae types including putative new variants and virulence‐related genes and clump formation among aggR‐positive Escherichia coli strains isolated in Thailand and Japan. (August 2014)

• Record Type: Journal Article
• Authors: Ito, Kenitiro; Matsushita, Shigeru; Yamazaki, Mitsugu; Moriya, Kazuo; Kurazono, Takayuki; Hiruta, Noriaki; Narimatsu, Hiroshi; Ueno, Nobuhiro; Isobe, Junko; Yatsuyanagi, Jun; Kumagai, Norimichi; Hashimoto, Michiko; Ratchtrachenchai, Orn‐Anong
• Is Part Of: Microbiology and immunology. Volume 58:Number 8(2014:Aug.)
• Page Start: 467
• Page End: 473
• Publication Date: 2014-08
• Subjects: Microbiology -- Periodicals; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Microbiology -- Periodicals; Microbiologie -- Périodiques; Immunologie -- Périodiques; 579
• DOI: 10.1111/1348-0421.12173
• Languages: English
• ISSNs: 0385-5600

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="mim12173-sec-0001" sec-type="section"> <p>Enteroaggregative <italic>Escherichia coli</italic> (EAggEC) are an important cause of diarrhea. Four types of AAF have been identified; however, their prevalence and association with virulence properties remain unclear. <italic>E. coli</italic> strains carrying the <italic>aggR</italic> gene as EAggEC that were isolated in Japan and Thailand (<italic>n</italic> = 90) were examined for AAF subunit genes, two toxin genes (<italic>pet</italic>/<italic>astA</italic>), and clump formation. The most prevalent AAF gene was <italic>hda</italic>A (28%), followed by <italic>aaf</italic><italic>A</italic> (20%), <italic>agg</italic><italic>A</italic> (12%), and <italic>agg3A</italic> (4%), as well as a putative new AAF sequence (25.6%). Retention status of the toxin genes and intensities of clump formation appeared to vary according to the AAF type.</p> </sec> </abstract>