The RpfC (Rv1884) atomic structure shows high structural conservation within the resuscitation‐promoting factor catalytic domain. Issue 8 (1st August 2014)

• Record Type: Journal Article
• Authors: Chauviac, Francois‐Xavier; Robertson, Giles; Quay, Doris H. X.; Bagnéris, Claire; Dumas, Christian; Henderson, Brian; Ward, John; Keep, Nicholas H.; Cohen‐Gonsaud, Martin
• Is Part Of: Acta crystallographica. Volume 70:Issue 8(2014:Aug.)
• Page Start: 1022
• Page End: 1026
• Publication Date: 2014-08-01
• Subjects: Crystallography -- Periodicals; Crystals -- Periodicals; 548
• DOI: 10.1107/S2053230X1401317X
• Languages: English
• ISSNs: 2053-230X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The first structure of the catalytic domain of RpfC (Rv1884), one of the resuscitation‐promoting factors (RPFs) from <italic>Mycobacterium tuberculosis</italic>, is reported. The structure was solved using molecular replacement once the space group had been correctly identified as twinned <italic>P</italic>2₁ rather than the apparent <italic>C</italic>222₁ by searching for anomalous scattering sites in <italic>P</italic>1. The structure displays a very high degree of structural conservation with the previously published structures of the catalytic domains of RpfB (Rv1009) and RpfE (Rv2450). This structural conservation highlights the importance of the versatile domain composition of the RPF family.</p> </abstract>