12/15‐Lipoxygenase deficiency reduces densities of mesenchymal stem cells in the dermis of wounded and unwounded skin. (17th July 2014)

• Record Type: Journal Article
• Authors: Hong, S.; Alapure, B.V.; Lu, Y.; Tian, H.; Wang, Q.
• Is Part Of: British journal of dermatology. Volume 171:Number 1(2014:Jul.)
• Page Start: 30
• Page End: 38
• Publication Date: 2014-07-17
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/bjd.12899
• Languages: English
• ISSNs: 0007-0963

Abstract

<abstract abstract-type="short" xml:lang="en" id="bjd12899-abs-0002"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>What's already known about this topic?</bold> </p> <p> <list id="bjd12899-list-0001" list-type="bullet"> <list-item> <p>Mesenchymal stem cells (MSCs) are known to be recruited into wounded skin and to promote healing.</p> </list-item> <list-item> <p>12/15‐Lipoxgenase (LOX) and its products are present in the skin.</p> </list-item> <list-item> <p>12/15‐LOX deficiency suppresses wound healing.</p> </list-item> </list> </p> <p> <bold>What does this study add?</bold> </p> <p> <list id="bjd12899-list-0002" list-type="bullet"> <list-item> <p>We have discovered for the first time that LOX deficiency reduces MSC densities in the dermis of wounded and unwounded skin.</p> </list-item> </list> </p> </abstract>