Early stationary phase culture supernatant accelerates growth of sputum cultures collected after initiation of anti‐tuberculosis treatment. (29th November 2013)

• Record Type: Journal Article
• Authors: Kolwijck, E.; Friedrich, S. O.; Karinja, M. N.; van Ingen, J.; Warren, R. M.; Diacon, A. H.; Drancourt, M.
• Is Part Of: Clinical microbiology and infection. Volume 20:Number 7(2014:Jul.)
• Page Start: O418
• Page End: O420
• Publication Date: 2013-11-29
• Subjects: Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1111/1469-0691.12441
• Languages: English
• ISSNs: 1198-743X

Abstract

<abstract abstract-type="main" id="clm12441-abs-0001"> <title>Abstract</title> <p>We investigated the effect of <italic>Mycobacterium tuberculosis</italic> culture supernatant added to sputum cultures collected during the first 8 weeks of anti‐tuberculosis treatment. With ongoing treatment duration, time to culture positivity decreased significantly in supernatant‐enriched cultures, possibly due to stimulation of dormant or slowly metabolizing <italic>M. tuberculosis</italic> cells.</p> </abstract>