Encapsulation of animal wax‐based organogels in alginate microparticles. Issue 20 (15th May 2014)

• Record Type: Journal Article
• Authors: Sagiri, Sai S.; Pal, Kunal; Basak, Piyali
• Is Part Of: Journal of applied polymer science. Volume 131:Issue 20(2014:Oct. 15)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2014-05-15
• Subjects: Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.40910
• Languages: English
• ISSNs: 0021-8995

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>Encapsulation of organogels is a novel perspective in the field of controlled drug delivery. This study reports encapsulation of lanolin based organogels within alginate microparticles. The microparticles were prepared by emulsification/internal gelation method. Microscopic studies suggested spherical shape of the microparticles. Fourier transform infrared, X‐ray diffraction and thermal studies confirmed the presence of organogels within the microparticles. Organogels containing microparticles showed improved drug (e.g., salicylic acid and metronidazole) entrapment efficiency. The release of the drugs from the microparticles was dependent on the pH of the dissolution medium. The release was diffusion mediated. The drug loaded microparticles showed antimicrobial activity against <italic>E. coli</italic> and <italic>B. subtilis</italic>. The preliminary study suggested that the encapsulation of the organogels may help prolonging the release of the drugs and hence may be tried as vehicles for controlled drug delivery. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. <bold>2014</bold>, <italic>131</italic>, 40910.</p> </abstract>