Course of depressive symptoms and treatment in the longitudinal assessment of bariatric surgery (LABS‐2) study. (25th March 2014)

• Record Type: Journal Article
• Authors: Mitchell, James E.; King, Wendy C.; Chen, Jia‐Yuh; Devlin, Michael J.; Flum, David; Garcia, Luis; Inabet, William; Pender, John R.; Kalarchian, Melissa A.; Khandelwal, Saurabh; Marcus, Marsha D.; Schrope, Beth; Strain, Gladys; Wolfe, Bruce; Yanovski, Susan
• Is Part Of: Obesity. Volume 22:Number 8(2014:Aug.)
• Page Start: 1799
• Page End: 1806
• Publication Date: 2014-03-25
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20738
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20738-sec-0001" sec-type="section"> <title>Objective</title> <p>To examine changes in depressive symptoms and treatment in the first 3 years following bariatric surgery.</p> </sec> <sec id="oby20738-sec-0002" sec-type="section"> <title>Methods</title> <p>The longitudinal assessment of bariatric surgery‐2 (LABS‐2) is an observational cohort study of adults (<italic>n</italic> = 2, 458) who underwent a bariatric surgical procedure at 1 of 10 US hospitals between 2006 and 2009. This study includes 2, 148 participants who completed the Beck depression inventory (BDI) at baseline and ≥ one follow‐up visit in years 1‐3.</p> </sec> <sec id="oby20738-sec-0003" sec-type="section"> <title>Results</title> <p>At baseline, 40.4% self‐reported treatment for depression. At least mild depressive symptoms (BDI score ≥ 10) were reported by 28.3%; moderate (BDI score 19‐29) and severe (BDI score ≥30) symptoms were uncommon (4.2 and 0.5%, respectively). Mild‐to‐severe depressive symptoms independently increased the odds (OR = 1.75; <italic>P</italic> = 0.03) of a major adverse event within 30 days of surgery. Compared with baseline, symptom severity was significantly lower at all follow‐up time points (e.g., mild‐to‐severe symptomatology was 8.9%, 6 months; 8.4%, 1year; 12.2%, 2 years; 15.6%, 3 years; ps < 0.001), but increased between 1 and 3 years postoperatively (<italic>P</italic> < 0.01). Change in depressive symptoms was significantly related to change in body mass index (<italic>r</italic> = 0.42; <italic>P</italic> < 0001).</p> </sec> <sec id="oby20738-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Bariatric surgery has a positive impact on depressive features. However, data suggest some deterioration in improvement after the first postoperative year. LABS‐2, #NCT00465829, <ext-link ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov/ct2/show/NCT00465829" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">http://www.clinicaltrials.gov/ct2/show/NCT00465829</ext-link>.</p> </sec> </abstract>