Efficient Method for the Synthesis of Functionalized Basic Maleimides. (16th December 2013)

• Record Type: Journal Article
• Authors: Salewska, Natalia; Milewska, Maria J.
• Is Part Of: Journal of heterocyclic chemistry. Volume 51:Number 4(2014)
• Page Start: 999
• Page End: 1003
• Publication Date: 2013-12-16
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.1651
• Languages: English
• ISSNs: 0022-152X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>A three‐step procedure involving <named-content content-type="reactionType" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">Diels–Alder</named-content> condensation of maleic anhydride with furane, formation of <italic>N</italic>‐substituted imide upon reaction with appropriate diamine, and a final retro <named-content content-type="reactionType" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">Diels–Alder</named-content> regeneration of the maleic carbon–carbon double bond is proposed for an unequivocal synthesis of <italic>N</italic>‐substituted basic maleimides. The novel method is characterized by mild reaction conditions, easy work‐up, high yields, and no need for additional <named-content content-type="reactionType" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">catalysis</named-content>.</p> </abstract>