Additive Effects in the Palladium‐Catalyzed Carboiodination of Chiral N‐Allyl Carboxamides1. Issue 30 (10th June 2014)

• Record Type: Journal Article
• Authors: Petrone, David A.; Yoon, Hyung; Weinstabl, Harald; Lautens, Mark
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 30(2014)
• Page Start: 7908
• Page End: 7912
• Publication Date: 2014-06-10
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201404007
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The use of Pd catalysis as a means to synthesize organic halides has recently received increased attention. Among the reported methods is the Pd‐catalyzed carboiodination, which uses extremely bulky ligands to facilitate carbon–halogen reductive elimination from Pd^II as the key catalytic step. When approaching substrates exhibiting low stereoselectivity, catalyst troubleshooting becomes difficult as there are few ligands known to promote the key reductive elimination. Herein, we present our finding that tertiary amines act as weakly coordinating ligands which significantly enhance diastereoselectivity in the Pd/QPhos‐catalyzed carboiodination of chiral N‐allyl carboxamides. This methodology allows efficient access to enantioenriched and densely functionalized dihydroisoquinolinones, and has been applied toward the asymmetric formal synthesis of (+)‐corynoline.</p> </abstract>