Base‐Controlled Selectivity in the Synthesis of Linear and Angular Fused Quinazolinones by a Palladium‐Catalyzed Carbonylation/Nucleophilic Aromatic Substitution Sequence1. Issue 29 (30th May 2014)

• Record Type: Journal Article
• Authors: Chen, Jianbin; Natte, Kishore; Spannenberg, Anke; Neumann, Helfried; Langer, Peter; Beller, Matthias; Wu, Xiao‐Feng
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 29(2014)
• Page Start: 7579
• Page End: 7583
• Publication Date: 2014-05-30
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201402779
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A new approach for the facile synthesis of fused quinazolinone scaffolds through a palladium‐catalyzed carbonylative coupling followed by an intramolecular nucleophilic aromatic substitution is described. The base serves as the key modulator: Whereas DBU gives rise to the linear isomers, Et₃N promotes the preferential formation of angular products. Interestingly, a light‐induced 4+4 reaction of the product was also observed.</p> </abstract>