Water‐Soluble Triarylboron Compound for ATP Imaging In Vivo Using Analyte‐Induced Finite Aggregation1. (6th June 2014)

• Record Type: Journal Article
• Authors: Li, Xiaoyan; Guo, Xudong; Cao, Lixia; Xun, Zhiqing; Wang, Shuangqing; Li, Shayu; Li, Yi; Yang, Guoqiang
• Is Part Of: Angewandte Chemie. Volume 126:Number 30(2014)
• Page Start: 7943
• Page End: 7947
• Publication Date: 2014-06-06
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201403918
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Adenosine 5′‐triphosphate (ATP) is a multifunctional molecule that participates in many important biological processes. Currently, fluorescence indicators for ATP with high performance are in demand. Reported herein is a novel water‐soluble triarylboron compound which displays an apparent ATP‐dependent fluorescence enhancement when dispersed in water. It can selectively recognize ATP from other bioactive substances in vitro and in vivo. The ATP‐induced finite aggregation endows the indicator with appreciable photostability and superior tolerance to environmental electrolytes. This indicator has been successfully applied to the ATP imaging in NIH/3T3 fibroblast cells. The difference in the ATP levels within the membrane and cytosol is clearly visible.</p> </abstract>