Mandibular reconstruction using a calcium phosphate/polyethylene glycol hydrogel carrier with BMP‐2. (13th June 2014)

• Record Type: Journal Article
• Authors: Gruber, Rudolf M.; Krohn, Sebastian; Mauth, Corinna; Dard, Michel; Molenberg, Aart; Lange, Katharina; Perske, Christina; Schliephake, Henning
• Is Part Of: Journal of clinical periodontology. Volume 41:Number 8(2014:Aug.)
• Page Start: 820
• Page End: 826
• Publication Date: 2014-06-13
• Subjects: Periodontics -- Periodicals; 617.6
• DOI: 10.1111/jcpe.12264
• Languages: English
• ISSNs: 0303-6979

Abstract

<abstract abstract-type="main" id="jcpe12264-abs-0001"> <title>Abstract</title> <sec id="jcpe12264-sec-0001" sec-type="section"> <title>Aim</title> <p>To test the hypothesis that a synthetic hydroxyapatite/<italic>β</italic>‐tricalcium phosphate (HA/TCP) construct combined with polyethylene glycol (PEG) hydrogel including recombinant human bone morphogenetic proteins‐2 (rhBMP‐2) enhances new bone formation compared with bone morphogenetic proteins‐2 (BMP‐2) delivered using the HA/TCP construct alone.</p> </sec> <sec id="jcpe12264-sec-0002" sec-type="section"> <title>Material and Methods</title> <p>Bilateral mandibular partial thickness 20 × 8 × 8 mm (L × W × H) alveolar defects were surgically created in the edentulated posterior mandible in 18 female minipigs. Randomized into two groups of nine animals each, the alveolar defects either received HA/TCP or HA/TCP/PEG with or without BMP‐2 (105 <italic>μ</italic>g/defect) in contra‐lateral sites using a split‐mouth design. Primary outcome, bone density (%) within four regions of interest, was evaluated following a 4‐week healing interval when the animals were killed for histometric analysis.</p> </sec> <sec id="jcpe12264-sec-0003" sec-type="section"> <title>Results</title> <p>Bone morphogenetic proteins‐2 loaded onto HA/TCP constructs significantly enhanced new bone formation compared with HA/TCP controls. Adding PEG apparently obstructed BMP‐2 induced bone formation.</p> </sec> <sec id="jcpe12264-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Polyethylene glycol compromises the osteogenic effect of BMP‐2.</p> </sec> </abstract>