Interleukin‐28B rs12979860 C allele: Protective against advanced fibrosis in chronic hepatitis C genotype 1 infection. Issue 7 (15th July 2014)

• Record Type: Journal Article
• Authors: Kitson, Matthew T; George, Jacob; Dore, Gregory J; Leung, Reynold; Button, Peter; McCaughan, Geoffrey W; Crawford, Darrell H G; Sievert, William; Weltman, Martin D; Cheng, Wendy S C; Roberts, Stuart K; CHARIOT Study Group
• Is Part Of: Journal of gastroenterology and hepatology. Volume 29:Issue 7(2014:Jul.)
• Page Start: 1458
• Page End: 1462
• Publication Date: 2014-07-15
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Liver Diseases -- Periodicals; 616.33
• DOI: 10.1111/jgh.12544
• Languages: English
• ISSNs: 0815-9319

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jgh12544-sec-0001" sec-type="section"> <title>Background and Aim</title> <p>While genetic polymorphisms upstream of the interleukin‐28B (<italic>IL28B</italic>) gene are associated with necroinflammatory activity grade in chronic hepatitis C virus genotype 1 (HCV‐1) infection, any association with fibrosis is less definitive. Pretreatment liver biopsies in a cohort of treatment‐naïve patients with HCV‐1 were analyzed to evaluate associations between liver histology, and the rs12979860 and rs8099917 <italic>IL28B</italic> single nucleotide polymorphisms.</p> </sec> <sec id="jgh12544-sec-0002" sec-type="section"> <title>Methods</title> <p>Two hundred sixty‐six patients with HCV‐1 infection and pretreatment liver biopsy were tested for the rs12979860 and rs8099917 single nucleotide polymorphisms. Predictors of advanced fibrosis (METAVIR F3/4) and high activity grade (A2/3) were identified using multivariable logistic regression analysis.</p> </sec> <sec id="jgh12544-sec-0003" sec-type="section"> <title>Results</title> <p>Forty‐four patients (16.5%) had advanced fibrosis and 141 patients (53.0%) high activity grade. Prevalence of rs12979860 <italic>IL28B</italic> genotype was: CC 45.7%, CT 42.7%, and TT 11.6%. Prevalence of advanced fibrosis was lower in those with <italic>IL28B</italic> CC genotype compared with those without (11.0% <italic>vs</italic> 21.3%; <italic>P</italic> = 0.03), with an increasing number of T alleles associated with a higher frequency of advanced fibrosis: CC 11.0%, CT 18.0%, TT 33.3% (<italic>P</italic> = 0.01). Predictors of advanced fibrosis on multivariate analysis were platelet count (odds ratio [OR] 0.98, 95% confidence interval [CI] 0.97–0.99; <italic>P</italic> < 0.0001), high activity grade (OR 5.68, 95% CI% 1.86–17.32; <italic>P</italic> = 0.002), <italic>IL28B</italic> rs12979860 CC genotype (OR 0.36, 95% CI 0.14–0.93; <italic>P</italic> = 0.03), and aspartate aminotransferase (OR 1.02, 95% CI 1.00–1.03; <italic>P</italic> = 0.046). No association was found between rs8099917 <italic>IL28B</italic> genotype and liver histology.</p> </sec> <sec id="jgh12544-sec-0004" sec-type="section"> <title>Conclusions</title> <p> <italic>IL28B</italic> rs12979860 CC genotype appears to be independently associated with a lower prevalence of advanced fibrosis stage in HCV‐1 infection. This association warrants further evaluation.</p> </sec> </abstract>