Is gingival bleeding a symptom of patients with type 1 von Willebrand disease? A case–control study. (24th June 2014)

• Record Type: Journal Article
• Authors: Weickert, Lisa; Miesbach, Wolfgang; Alesci, Sonja Rosa; Eickholz, Peter; Nickles, Katrin
• Is Part Of: Journal of clinical periodontology. Volume 41:Number 8(2014:Aug.)
• Page Start: 766
• Page End: 771
• Publication Date: 2014-06-24
• Subjects: Periodontics -- Periodicals; 617.6
• DOI: 10.1111/jcpe.12274
• Languages: English
• ISSNs: 0303-6979

Abstract

<abstract abstract-type="main" id="jcpe12274-abs-0001"> <title>Abstract</title> <sec id="jcpe12274-sec-0001" sec-type="section"> <title>Background</title> <p>Von Willebrand disease (VWD) is the most common inherent bleeding disorder resulting in prolonged bleeding time. Gingival bleeding is a frequently reported symptom of VWD. However, gingival bleeding is also known as a leading symptom of plaque‐induced gingivitis and untreated periodontal disease. Gingival bleeding in VWD patients (VWD) may be triggered by gingival inflammation and not a genuine symptom. Thus, this study evaluated whether type 1 VWD determines an increased susceptibility to gingival bleeding in response to the oral biofilm.</p> </sec> <sec id="jcpe12274-sec-0002" sec-type="section"> <title>Methods</title> <p>Fifty cases and 40 controls were examined haematologically (VWF antigen, VWF Ristocetin cofactor, factor VIII activity) and periodontally [Gingival Bleeding Index (GBI), bleeding on probing (BOP), Plaque Control Record (PCR), periodontal inflamed surface area (PISA), vertical probing attachment level].</p> </sec> <sec id="jcpe12274-sec-0003" sec-type="section"> <title>Results</title> <p>GBI was significantly higher in controls (12.2%) than in VWD (10%). The study failed to find a significant difference regarding BOP between VWD (17%) and controls (17.2%). Multiple regressions identified PCR and PISA to be associated with GBI and BOP. VWD was negatively associated with GBI. Smoking and number of remaining teeth was negatively associated with BOP.</p> </sec> <sec id="jcpe12274-sec-0004" sec-type="section"> <title>Conclusion</title> <p>VWD is not associated with a more pronounced inflammatory response to the oral biofilm in terms of GBI and BOP.</p> </sec> </abstract>