Coupling Interval Dispersion and Body Mass Index Are Independent Predictors of Idiopathic Premature Ventricular Complex‐Induced Cardiomyopathy. (19th March 2014)

• Record Type: Journal Article
• Authors: KAWAMURA, MITSUHARU; BADHWAR, NITISH; VEDANTHAM, VASANTH; TSENG, ZIAN H.; LEE, BYRON K.; LEE, RANDALL J.; MARCUS, GREGORY M.; OLGIN, JEFFREY E.; GERSTENFELD, EDWARD P.; SCHEINMAN, MELVIN M.
• Is Part Of: Journal of cardiovascular electrophysiology. Volume 25:Number 7(2014:Jul.)
• Page Start: 756
• Page End: 762
• Publication Date: 2014-03-19
• Subjects: Blood vessels -- Physiology -- Periodicals; Electrophysiology -- Periodicals; Heart -- Physiology -- Periodicals; 612.1
• DOI: 10.1111/jce.12391
• Languages: English
• ISSNs: 1045-3873

Abstract

<abstract abstract-type="main"> <title>Predictors of LV Dysfunction with Idiopathic PVC</title> <sec id="jce12391-sec-0010" sec-type="section"> <title>Introduction</title> <p>Patients with frequent premature ventricular complexes (PVCs) might be at risk for the developing or exacerbation of left ventricular (LV) dysfunction. However, some patients with a high‐PVC burden do not develop cardiomyopathy, while other patients with low‐PVC burden can develop cardiomyopathy. The purpose of this study was to evaluate the positive predictors of idiopathic PVCs‐induced cardiomyopathy.</p> </sec> <sec id="jce12391-sec-0020" sec-type="section"> <title>Methods and Results</title> <p>We investigated 214 patients undergoing successful ablation of PVCs who had no other causes of cardiomyopathy. We divided the study cohort into 2 groups: ejection fraction (EF) ≥ 50% (normal LV) and EF < 50% (LV dysfunction). We analyzed the clinical characteristics, including the electrocardiogram and findings at electrophysiology study. Among these patients, 51 (24%) had reduced LVEF and 163 (76%) had normal LV function. Patients with LV dysfunction had significantly longer coupling interval (CI) dispersion (maximum‐CI–minimum‐CI) and had significantly higher PVC burden compared to those with normal LV function (CI‐dispersion: 115 ± 25 milliseconds vs. 94 ± 19 milliseconds; P < 0.001; PVC burden: 19% vs. 15%; P = 0.04). Furthermore, patients with LV dysfunction had significantly higher body mass index (BMI) compared to those with normal LV function (BMI > 30 kg/m<sup>2</sup>; 37% vs. 13%; P = 0.001). Logistic regression analysis showed that CI‐dispersion, PVC burden, and BMI (>30 kg/m<sup>2</sup>) are independent predictors of PVC‐induced cardiomyopathy.</p> </sec> <sec id="jce12391-sec-0030" sec-type="section"> <title>Conclusions</title> <p>In addition to the PVC burden, the CI‐dispersion and BMI are associated with PVC‐induced cardiomyopathy.</p> </sec> </abstract>