Reductions in resistance exercise‐induced hyperglycaemic episodes are associated with circulating interleukin‐6 in Type 1 diabetes. Issue 8 (25th April 2014)

• Record Type: Journal Article
• Authors: Turner, D.; Luzio, S.; Kilduff, L. P.; Gray, B. J.; Dunseath, G.; Bain, S. C.; Campbell, M. D.; West, D. J.; Bracken, R. M.
• Is Part Of: Diabetic medicine. Volume 31:Issue 8(2014:Aug.)
• Page Start: 1009
• Page End: 1013
• Publication Date: 2014-04-25
• Subjects: Diabetes -- Periodicals; 616.462
• DOI: 10.1111/dme.12462
• Languages: English
• ISSNs: 0742-3071

Abstract

<abstract abstract-type="main" id="dme12462-abs-0001"> <title>Abstract</title> <sec id="dme12462-sec-0001" sec-type="section"> <title>Aims</title> <p>To determine the influence of different volumes of resistance exercise on circulating interleukin‐6 (IL‐6) and to explore the relationships between IL‐6 and glycaemia.</p> </sec> <sec id="dme12462-sec-0002" sec-type="section"> <title>Methods</title> <p>Eight participants with complication‐free Type 1 diabetes, whose mean ± <sc>sem</sc> age was 38 (6) years, mean ± <sc>sem</sc> HbA<sub>1c</sub> concentration was 71 ±11 mmol/mol (8.7 ±1.0%) and mean ± <sc>sem</sc> Type 1 diabetes duration was 15 ±13 years, attended the research facility after an overnight fast on four separate occasions, having administered their basal insulin the night before (glargine 27.5±3.1U, <italic>n</italic>=8), but omitted morning rapid‐acting insulin. Participants completed either a one‐set (14‐min), two‐set (28‐min), or three‐set (42‐min) resistance exercise trial (eight exercises × 10 repetitions) at 67±3% one‐repetition maximum followed by a 60‐min recovery, or a resting control trial. Venous blood samples were taken before and after exercise. Data were analysed using repeated‐measures <sc>anova</sc> (<italic>P</italic>≤0.05).</p> </sec> <sec id="dme12462-sec-0003" sec-type="section"> <title>Results</title> <p>Whereas IL‐6 levels remained similar to baseline levels after one set of resistance exercises (30 min, <italic>P=</italic>0.287; 60 min, <italic>P</italic>=0.318), IL‐6 levels were > baseline levels at 60 min post‐exercise after a two‐set exercise trial (2.94 ± 0.94 pg/ml, <italic>P=</italic>0.002) and doubled at both 30 min (4.01 ± 1.00 pg/ml, <italic>P=</italic>0.048) and 60 min (4.28 ± 1.25 pg/ml, <italic>P=</italic>0.084) post‐exercise after the three‐set resistance exercise trial. Post‐exercise blood glucose area under the curve (mmol/l/60 min) was greater after both the one‐set (<italic>P=</italic>0.025) and two‐set trials <italic>(P</italic>=0.008), than after the control trial, but similar between the three‐set trial and the control trial (<italic>P=</italic>0.240). The rise in IL‐6 from baseline to peak concentration significantly correlated inversely with blood glucose area under the curve (<italic>r</italic>=‐0.65, <italic>P=</italic>0.041).</p> </sec> <sec id="dme12462-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Circulating IL‐6 is increased by resistance exercise in a volume‐dependent manner, and resistance exercise‐induced increases in IL‐6 correlated with reductions in post‐exercise hyperglycaemia in Type 1 diabetes, suggesting a role for IL‐6 in improving post‐resistance exercise glycaemic disturbances in Type 1 diabetes.</p> <p>(Clinical Trials Registry No: ISRCTN60407046)</p> </sec> </abstract>