Effect of continuous positive airway pressure therapy on sexual function and serum testosterone in males with type 2 diabetes and obstructive sleep apnoea. (28th January 2014)

• Record Type: Journal Article
• Authors: Knapp, Arthur; Myhill, Paul C.; Davis, Wendy A.; Peters, Kirsten E.; Hillman, David; Hamilton, Emma J.; Lim, Ee Mun; Davis, Timothy M. E.
• Is Part Of: Clinical endocrinology. Volume 81:Number 2(2014:Aug.)
• Page Start: 254
• Page End: 258
• Publication Date: 2014-01-28
• Subjects: Endocrinology -- Periodicals; 616.4005
• DOI: 10.1111/cen.12401
• Languages: English
• ISSNs: 0300-0664

Abstract

<abstract abstract-type="main" id="cen12401-abs-0001"> <title>Summary</title> <sec id="cen12401-sec-0001" sec-type="section"> <title>Objective</title> <p>There have been no studies of the effect of continuous positive airway pressure (CPAP) therapy on erectile dysfunction (ED) and serum testosterone in men with type 2 diabetes and obstructive sleep apnoea (OSA), a patient group at increased risk of ED and hypogonadism. The aim of this study was to determine whether CPAP improves sexual and gonadal function in males with type 2 diabetes and a pre‐CPAP apnoea–hypopnoea index >15/h.</p> </sec> <sec id="cen12401-sec-0002" sec-type="section"> <title>Design</title> <p>Substudy of a trial assessing the effect of 3 months of CPAP on cardiovascular risk in type 2 diabetes.</p> </sec> <sec id="cen12401-sec-0003" sec-type="section"> <title>Patients</title> <p>Of 35 males starting CPAP, 27 (mean ± SD age 65·4 ± 9·6 years, median [interquartile range] diabetes duration 12·1 [5·2–15·3] years) completed the trial.</p> </sec> <sec id="cen12401-sec-0004" sec-type="section"> <title>Measurements</title> <p>Serum total and free testosterone, responses to the Androgen Deficiency in the Aging Aale (ADAM) and Sexual Health Inventory for Men (SHIM) questionnaires.</p> </sec> <sec id="cen12401-sec-0005" sec-type="section"> <title>Results</title> <p>There were no significant changes in mean total or free testosterone (baseline concentrations 12·7 ± 4·5 n<sc>m</sc> and 0·26 ± 0·07 p<sc>m</sc>, respectively), or SHIM score (baseline 13 [5–17]), after 3 months of CPAP (<italic>P </italic>><italic> </italic>0·20). The ADAM score (baseline 6·2 ± 2·1) fell after 1 month (to 5·0 ± 2·6) and was maintained at this level at 3 months (<italic>P </italic>=<italic> </italic>0·015). The Epworth Sleepiness Scale score decreased and self‐reported physical activity increased over 3 months (<italic>P </italic>≤<italic> </italic>0·017) without a change in body mass index (<italic>P </italic>=<italic> </italic>1·00).</p> </sec> <sec id="cen12401-sec-0006" sec-type="section"> <title>Conclusions</title> <p>These findings imply that CPAP therapy improves somnolence and promotes exercise in men with type 2 diabetes, but that there is no direct benefit for gonadal or sexual function.</p> </sec> </abstract>