Ectopic blastema induction by nerve deviation and skin wounding: a new regeneration model in Xenopus laevis. Issue 2 (28th May 2014)

• Record Type: Journal Article
• Authors: Mitogawa, Kazumasa; Hirata, Ayako; Moriyasu, Miyuki; Makanae, Aki; Miura, Shinichirou; Endo, Tetsuya; Satoh, Akira
• Is Part Of: Regeneration. Volume 1:Issue 2(2014)
• Page Start: 26
• Page End: 36
• Publication Date: 2014-05-28
• Subjects: Regeneration (Biology) -- Periodicals; 571.889
• DOI: 10.1002/reg2.11
• Languages: English
• ISSNs: 2052-4412

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="reg211-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>We successfully applied the accessory limb model (ALM) of axolotls to Xenopus laevis, a species with a regenerate capacity intermediate between axolotls and higher vertebrates.</p> <p>In contrast to axolotl ALM blastemas, Xenopus ALM‐induced blastemas could not form cartilage unless bone was damaged.</p> <p>The Xenopus ALM model may facilitate the identification of gene expression programs and signaling pathways regulating cartilage, bone, and muscle formation during limb regeneration. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pghtb20598" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>