Crystal structure determination of anti‐DNA Fab A52. Issue 8 (18th February 2014)

• Record Type: Journal Article
• Authors: Stanfield, Robyn L.; Eilat, Dan
• Is Part Of: Proteins. Volume 82:Issue 8(2014)
• Page Start: 1674
• Page End: 1678
• Publication Date: 2014-02-18
• Subjects: Proteins -- Periodicals; Proteins -- Periodicals; 572.6
• DOI: 10.1002/prot.24514
• Languages: English
• ISSNs: 0887-3585

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>A52 is a murine monoclonal antibody isolated from autoimmune New Zealand Black/New Zealand White F1 mice that recognizes single and double stranded DNA. This mouse strain spontaneously develops systemic lupus erythematosus‐like symptoms and has served as a model for that disease for many years. The 1.62 Å crystal structure of the A52 Fab fragment reveals an H3 complementarity determining region with four closely spaced arginine residues, creating a positively charged surface to accommodate bound DNA. Proteins 2014; 82:1674–1678. © 2014 Wiley Periodicals, Inc.</p> </abstract>