BDNF Val66Met polymorphism in primary adult‐onset dystonia: A case‐control study and meta‐analysis. Issue 8 (12th June 2014)

• Record Type: Journal Article
• Authors: Gómez‐Garre, Pilar; Huertas‐Fernández, Ismael; Cáceres‐Redondo, María Teresa; Alonso‐Canovas, Araceli; Bernal‐Bernal, Inmaculada; Blanco‐Ollero, Alberto; Bonilla‐Toribio, Marta; Burguera, Juan Andrés; Carballo, Manuel; Carrillo, Fátima; Catalán‐Alonso, María José; Escamilla‐Sevilla, Francisco; Espinosa‐Rosso, Raúl; Fernández‐Moreno, María Carmen; García‐Caldentey, Juan; García‐Moreno, José Manuel; García‐Ruiz, Pedro José; Giacometti‐Silveira, Sandra; Gutiérrez‐García, Javier; Jesús, Silvia; López‐Valdés, Eva; Martínez‐Castrillo, Juan Carlos; Martínez‐Torres, Irene; Medialdea‐Natera, María Pilar; Méndez‐Lucena, Carolina; Mínguez‐Castellanos, Adolfo; Moya, Miguel; Ochoa‐Sepulveda, Juan José; Ojea, Tomás; Rodríguez, Nuria; Sillero‐Sánchez, Miriam; Vargas‐González, Laura; Mir, Pablo;
• Is Part Of: Movement disorders. Volume 29:Issue 8(2014)
• Page Start: 1083
• Page End: 1086
• Publication Date: 2014-06-12
• Subjects: Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.25938
• Languages: English
• ISSNs: 0885-3185

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="mds25938-sec-0001" sec-type="section"> <title>Background</title> <p>A polymorphism in brain‐derived neurotrophic factor (BDNF) (Val66Met) has been reported as a risk factor in primary dystonia. However, overall the results have been inconclusive. Our aim was to clarify the association of Val66Met with primary dystonia, and with the most prevalent clinical subtypes, cervical dystonia and blepharospasm.</p> </sec> <sec id="mds25938-sec-0002" sec-type="section"> <title>Methods</title> <p>We conducted a Spanish multicenter case‐control study (including 680 primary dystonia patients and 788 healthy controls) and performed a meta‐analysis integrating our study and six previously published studies (including a total of 1, 936 primary dystonia patients and 2, 519 healthy controls).</p> </sec> <sec id="mds25938-sec-0003" sec-type="section"> <title>Results</title> <p>We found no allelic or genotypic association with primary dystonia, cervical dystonia, or blepharospasm risks, for the allele A (Met) from a BDNF Val66Met polymorphism in our case‐control study. This was confirmed by results from our meta‐analysis in white and mixed ethnic populations in any genetic model.</p> </sec> <sec id="mds25938-sec-0004" sec-type="section"> <title>Conclusion</title> <p>We did not find any evidence supporting the association of the BDNF Val66Met polymorphism with primary dystonia. © 2014 International Parkinson and Movement Disorder Society</p> </sec> </abstract>