Gender, age‐related, and regional differences of the magnetization transfer ratio of the cortical and subcortical brain gray matter. Issue 2 (August 2014)

• Record Type: Journal Article
• Authors: Mascalchi, Mario; Toschi, Nicola; Ginestroni, Andrea; Giannelli, Marco; Nicolai, Emanuele; Aiello, Marco; Soricelli, Andrea; Diciotti, Stefano
• Is Part Of: Journal of magnetic resonance imaging. Volume 40:Issue 2(2014)
• Page Start: spcone
• Page End: spcone
• Publication Date: 2014-08
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24708
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24708-sec-0001" sec-type="section"> <title>Purpose</title> <p>To explore gender, age‐related, and regional differences of magnetization transfer ratio (MTR) of brain cortical and subcortical gray matter (GM).</p> </sec> <sec id="jmri24708-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>In all, 102 healthy subjects (51 women and 51 men; range 25–84 years) were examined with 3‐mm thick MT images. We assessed MTR in automatically segmented GM structures including frontal, parietal‐insular, temporal, and occipital cortex, caudate, pallidus and putamen, and cerebellar cortex. A general linear model analysis was conducted to ascertain the linear and quadratic relationship among the MTR and gender, age, and anatomical structure.</p> </sec> <sec id="jmri24708-sec-0003" sec-type="section"> <title>Results</title> <p>The effect of gender was borderline (<italic>P</italic> = 0.07) in all GM structures (with higher MTR values in men), whereas age showed a significant linear as well as quadratic effect in all cortical and subcortical GM structures (<italic>P</italic> ≤ 0.001). Quadratic age‐related decrease in MTR began at about 40 years of age. Mean and standard deviation (SD) of MTR had the following decreasing order: thalamus (58.3 + 0.8), pallidus (56.8 ± 1.3), caudate (55.5 ± 1.6) and putamen (54.6 ± 1.1); temporal (56.8 ± 0.9), parietal‐insular (56.8 ± 1.1), frontal (56.5 ± 1.1), occipital (55.4 ± 1.0) and cerebellar (53.2 ± 1.0) cortex. In post‐hoc testing, all regional pairwise differences were statistically significant except pallidus vs. temporal or parietal‐insular cortex, caudate vs. occipital cortex, frontal vs. parietal‐insular or temporal cortex.</p> </sec> <sec id="jmri24708-sec-0004" sec-type="section"> <title>Conclusion</title> <p>MTR of the cortical and subcortical brain GM structures decreases quadratically after midlife and shows significant regional differences. <bold>J. Magn. Reson. Imaging 2014;40:360–366</bold> © <bold>2013 Wiley Periodicals, Inc</bold>.</p> </sec> </abstract>