In vivo whole‐brain T1‐rho mapping across adulthood: Normative values and age dependence. Issue 2 (13th November 2013)

• Record Type: Journal Article
• Authors: Watts, Richard; Andrews, Trevor; Hipko, Scott; Gonyea, Jay V.; Filippi, Christopher G.
• Is Part Of: Journal of magnetic resonance imaging. Volume 40:Issue 2(2014)
• Page Start: 376
• Page End: 382
• Publication Date: 2013-11-13
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24358
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24358-sec-0001" sec-type="section"> <title>Purpose</title> <p>To report a systematic investigation of variations in brain T<sub>1ρ</sub> (T1‐rho) values over adulthood, and present normative values for cortical gray matter, juxtacortical white matter, selected white matter tracts and subcortical structures.</p> </sec> <sec id="jmri24358-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Forty‐one healthy control subjects (23 males aged 18–76 years and 18 females aged 21–73 years) were imaged at 3.0 Tesla (T) using a novel whole‐brain T<sub>1ρ</sub>‐weighted fluid suppressed three‐dimensional turbo spin echo technique. T<sub>1ρ</sub> maps were calculated and atlas‐based segmentation used to determine regional T<sub>1ρ</sub> values. Linear regression was used to determine changes in T<sub>1ρ</sub> with age.</p> </sec> <sec id="jmri24358-sec-0003" sec-type="section"> <title>Results</title> <p>T<sub>1ρ</sub> values showed significant decreases with age in cortical gray matter (<italic>P</italic> < 0.001), left and right caudate (<italic>P</italic> = 0.004/0.006), putamen (<italic>P</italic> = 0.001, <italic>P</italic> < 0.001), hippocampus (<italic>P</italic> = 0.039/0.010), amygdala (<italic>P</italic> = 0.002/0.001), and nucleus accumbens (<italic>P</italic> = 0.001/0.002). Significant increases with age (<italic>P</italic> < 0.05) were observed in all the white matter tracts considered, except the corticospinal tracts and forceps major.</p> </sec> <sec id="jmri24358-sec-0004" sec-type="section"> <title>Conclusion</title> <p>T<sub>1ρ</sub> demonstrates changes related to the processes of normal aging. <bold>J. Magn. Reson. Imaging 2014;40:376–382</bold>. © <bold>2013 Wiley Periodicals, Inc</bold>.</p> </sec> </abstract>