Carbofuran Induced Oxidative Stress Mediated Alterations in Na+‐K+‐ATPase Activity in Rat Brain: Amelioration by Vitamin E. Issue 7 (27th May 2014)

• Record Type: Journal Article
• Authors: Jaiswal, Sunil Kumar; Siddiqi, Nikhat Jamal; Sharma, Bechan
• Is Part Of: Journal of biochemical and molecular toxicology. Volume 28:Issue 7(2014:Jul.)
• Page Start: 320
• Page End: 327
• Publication Date: 2014-05-27
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Toxicology -- Periodicals; 574
• DOI: 10.1002/jbt.21568
• Languages: English
• ISSNs: 1095-6670

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>Pesticides cause oxidative stress and adversely influence Na⁺‐K⁺‐ATPase activity in animals. Since impact of carbofuran has not been properly studied in the mammalian brain, the ability of carbofuran to induce oxidative stress and modulation in Na⁺‐K⁺‐ATPase activity and its amelioration by vitamin E was performed. The rats divided into six groups received two different doses of carbofuran (15% and 30% LD₅₀) for 15 days. The results suggested that the carbofuran treatment caused a significant elevation in levels of malonaldehyde and reduced glutathione and sharp inhibition in the activities of super oxide dismutase, catalase, and glutathione‐<italic>S</italic>‐transferase; the effect being dose dependent. Carbofuran at different doses also caused sharp reduction in the activity of Na⁺‐K⁺‐ATPase. The pretreatment of vitamin E, however, showed a significant recovery in these indices. The pretreatment of rats with vitamin E offered protection from carbofuran‐induced oxidative stress.</p> </abstract>