Analysis of the association of COL2A1 and IGF‐1 with mandibular prognathism in a Chinese population. (5th January 2014)

• Record Type: Journal Article
• Authors: Xue, F.; Rabie, A. B. M.; Luo, G.
• Is Part Of: Orthodontics and craniofacial research. Volume 17:Number 3(2014:Aug.)
• Page Start: 144
• Page End: 149
• Publication Date: 2014-01-05
• Subjects: Skull -- Growth -- Periodicals; Facial bones -- Growth -- Periodicals; Orthodontics -- Periodicals; Orthodontics, Corrective -- Periodicals; Orthodontic appliances -- Periodicals; 617.51
• DOI: 10.1111/ocr.12038
• Languages: English
• ISSNs: 1601-6335

Abstract

<abstract abstract-type="main" id="ocr12038-abs-0001"> <title>Structured Abstract</title> <sec id="ocr12038-sec-0001" sec-type="section"> <title>Objective</title> <p>In this study, we performed a case–control association analysis to determine whether the candidate genes <italic>COL2A1</italic> and <italic>IGF‐1</italic> are susceptibility genes for mandibular prognathism (MP).</p> </sec> <sec id="ocr12038-sec-0002" sec-type="section"> <title>Methods</title> <p>Eleven and five single‐nucleotide polymorphisms (SNPs) located in <italic>COL2A1</italic> and <italic>IGF‐1</italic>, respectively, were selected and genotyped in 211 cases and 224 controls. The individual SNPs and the relevant haplotypes were analyzed and tested for an association with MP, to identify genes potentially associated with MP.</p> </sec> <sec id="ocr12038-sec-0003" sec-type="section"> <title>Results</title> <p>In the analysis of individual SNPs, the SNP rs1793953 in the <italic>COL2A1</italic> gene showed a possible association with MP with regard to allelic frequency and genotypic distribution (<italic>p </italic>=<italic> </italic>0.031; <italic>p </italic>=<italic> </italic>0.025, respectively) in the 211 cases and 224 controls. The A allele of rs1793953 was associated with a significantly decreased risk of MP (OR: 0.74; 95% CI: 0.58–0.97). Linkage disequilibrium and haplotype analysis revealed that MP was not associated with haplotypes that included the rs1793953 alleles. <italic>IGF‐1</italic> gene did not show the association with MP.</p> </sec> <sec id="ocr12038-sec-0004" sec-type="section"> <title>Conclusion</title> <p>An association between polymorphism in the <italic>COL2A1</italic> gene and MP was observed. The results suggested that the <italic>COL2A1</italic> gene could be a new susceptibility gene for use in the study of genetic risk factors for MP.</p> </sec> </abstract>