Effect on Renal Function of Restoration of Euthyroidism in Hyperthyroid Cats with Iatrogenic Hypothyroidism. (28th April 2014)

• Record Type: Journal Article
• Authors: Williams, T.L.; Elliott, J.; Syme, H.M.
• Is Part Of: Journal of veterinary internal medicine. Volume 28:Number 4(2014:Jul./Aug.)
• Page Start: 1251
• Page End: 1255
• Publication Date: 2014-04-28
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.12359
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim12359-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim12359-sec-0001" sec-type="section"> <title>Background</title> <p>Iatrogenic hypothyroidism is associated with an increased incidence of azotemia after treatment of hyperthyroidism, and decreased survival time in azotemic hyperthyroid cats.</p> </sec> <sec id="jvim12359-sec-0002" sec-type="section"> <title>Hypothesis</title> <p>Restoration of euthyroidism will decrease plasma creatinine concentrations.</p> </sec> <sec id="jvim12359-sec-0003" sec-type="section"> <title>Animals</title> <p>Nineteen client‐owned, methimazole‐ or carbimazole‐treated, hyperthyroid cats with documented iatrogenic hypothyroidism (based on subnormal plasma total thyroxine concentrations [TT4] and increased plasma thyroid‐stimulating hormone concentrations).</p> </sec> <sec id="jvim12359-sec-0004" sec-type="section"> <title>Methods</title> <p>Prospective interventional study. Doses of antithyroid medication were reduced until euthyroidism was restored (TT4 10–40 nmol/L). Plasma creatinine concentration and selected other clinicopathologic variables were evaluated before and after restoration of euthyroidism and compared by nonparametric statistics. Data are presented as median [25th, 75th percentile].</p> </sec> <sec id="jvim12359-sec-0005" sec-type="section"> <title>Results</title> <p>Restoration of euthyroidism was associated with a significant decrease in plasma creatinine concentrations (2.61 [1.90, 3.26] mg/dL versus 2.07 [1.42, 2.82] mg/dL; <italic>P</italic> < .001) and body weight (4.03 [3.59, 4.53] kg versus 3.89 [3.34, 4.18] kg; <italic>P</italic> = .019), and a significant increase in packed cell volume (30 [28, 39]% versus 34 [29, 39]%; <italic>P</italic> = .038), heart rate (174 [163, 201] bpm versus 190 [164, 202] bpm; <italic>P</italic> = .009), and plasma alkaline phosphatase activity (26.6 [17.0, 33.0] IU/L versus 38.0 [23.5, 46.5] IU/L; <italic>P</italic> < .001).</p> </sec> <sec id="jvim12359-sec-0006" sec-type="section"> <title>Conclusions and Clinical Importance</title> <p>Restoration of euthyroidism in medically treated hyperthyroid cats with iatrogenic hypothyroidism causes a reduction in plasma creatinine concentrations, and thus might improve renal function; however, this could be influenced by concurrent changes in body weight.</p> </sec> </abstract>