Direct Assembly of 2‐Oxazolidinones by Chemical Fixation of Carbon Dioxide. Issue 29 (6th June 2014)

• Record Type: Journal Article
• Authors: Niemi, Teemu; Perea‐Buceta, Jesus E.; Fernández, Israel; Alakurtti, Sami; Rantala, Erika; Repo, Timo
• Is Part Of: Chemistry. Volume 20:Issue 29(2014)
• Page Start: 8867
• Page End: 8871
• Publication Date: 2014-06-06
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201402368
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The reaction of β‐ and γ‐haloamines with carbon dioxide to give pharmaceutically relevant 2‐oxazolidinones and 1, 3‐dioxazin‐2‐ones, was found to proceed efficiently in the presence of a base and in the absence of catalyst. After optimization of reaction conditions, the system was successfully expanded to a variety of haloamines, even at multigram scale. The reaction was further studied <italic>in silico</italic> by DFT calculations.</p> </abstract>