Cover Picture: Photoinduced Reduction of PtIV within an Anti‐Proliferative PtIV–Texaphyrin Conjugate (Chem. Eur. J. 29/2014). Issue 29 (14th July 2014)

• Record Type: Journal Article
• Authors: Thiabaud, Grégory; Arambula, Jonathan F.; Siddik, Zahid H.; Sessler, Jonathan L.
• Is Part Of: Chemistry. Volume 20:Issue 29(2014)
• Page Start: 8809
• Page End: 8809
• Publication Date: 2014-07-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201490117
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Novel platinum(IV)–texaphyrin conjugates</bold> were designed and synthesized in order to target cancer cells preferentially and to deliver platinum. Protected from light, these compounds are inert in aqueous environments and do not interact with DNA. However, following exposure to ambient light, a reduced, active Pt^II species, namely cisplatin, is released and binds to DNA. As a result, potent anti‐proliferative activity in ovarian cancer cell lines is observed for the Pt^IV–texaphyrin conjugates. For more details see the Full Paper by J. L. Sessler et al. on page <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">8942 ff.</ext-link><boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pghqbcf8w1" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>