Pharyngeal spasticity due to dantrolene. (12th April 2014)

• Record Type: Journal Article
• Authors: Locatelli, F.; Pozzi, M.; Avantaggiato, P.; Lanfranchi, M.; Tufarulo, L.; Amorelli, V.; Rizzi, G.; Radice, S.; Galbiati, S.; Clementi, E.; Strazzer, S.
• Is Part Of: Journal of clinical pharmacy and therapeutics. Volume 39:Number 4(2014:Aug.)
• Page Start: 449
• Page End: 451
• Publication Date: 2014-04-12
• Subjects: Clinical pharmacology -- Periodicals; Chemotherapy -- Periodicals; 615
• DOI: 10.1111/jcpt.12161
• Languages: English
• ISSNs: 0269-4727

Abstract

<abstract abstract-type="main" id="jcpt12161-abs-0001"> <title>Summary</title> <sec id="jcpt12161-sec-0001" sec-type="section"> <title>What is known and objective</title> <p>Dantrolene can be combined with baclofen to better treat spasticity, but may cause muscular weakness and dysphagia. We instead describe a pharyngeal spasm due to dantrolene.</p> </sec> <sec id="jcpt12161-sec-0002" sec-type="section"> <title>Case summary</title> <p>A 12‐year‐old male received dantrolene 3 mg/kg/day in adjunct to baclofen 2 mg/kg/day, to improve spasticity. After 5 days of full‐dose dantrolene, his dysphagia worsened and he developed pharyngeal spasm. Dantrolene was suspected for an adverse reaction and removed. The patient subsequently improved.</p> </sec> <sec id="jcpt12161-sec-0003" sec-type="section"> <title>What is new and conclusion</title> <p>Causality analysis determined a probable relationship between dantrolene and pharyngeal spasm. This may be due to direct muscle contraction by dantrolene, an effect seen previously <italic>in vitro</italic>.</p> </sec> </abstract>