Hospital‐acquired pressure ulcers and risk of hospital mortality in intensive care patients on mechanical ventilation. Issue 4 (22nd May 2014)

• Record Type: Journal Article
• Authors: Manzano, Francisco; Pérez‐Pérez, Ana M.; Martínez‐Ruiz, Susana; Garrido‐Colmenero, Cristina; Roldan, Delphine; Jiménez‐Quintana, María del Mar; Sánchez‐Cantalejo, Emilio; Colmenero, Manuel
• Is Part Of: Journal of evaluation in clinical practice. Volume 20:Issue 4(2014)
• Page Start: 362
• Page End: 368
• Publication Date: 2014-05-22
• Subjects: Clinical medicine -- Periodicals; 616.005
• DOI: 10.1111/jep.12137
• Languages: English
• ISSNs: 1356-1294

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jep12137-sec-0001" sec-type="section"> <title>Rationale, aims and objectives</title> <p>Pressure ulcers (PUs) are a common and serious complication in critically ill patients. The aim of this study was to evaluate the relationship between the development of a PU and hospital mortality in patients requiring mechanical ventilation (MV) in an intensive care unit (ICU).</p> </sec> <sec id="jep12137-sec-0002" sec-type="section"> <title>Methods</title> <p>A prospective cohort study was performed over two years in patients requiring MV for ≥ 24 hours in a medical‐surgical ICU. Primary outcome measure was hospital mortality and main independent variable was the development of a PU grade ≥ II. Hazard ratios (HRs) were calculated using a Cox model with time‐dependent covariates.</p> </sec> <sec id="jep12137-sec-0003" sec-type="section"> <title>Results</title> <p>Out of 563 patients in the study, 110 (19.5%) developed a PU. Overall hospital mortality was 48.7%. In the adjusted multivariate model, PU onset was a significant independent predictor of mortality (adjusted HR, 1.28; 95% confidence interval, 1.003–1.65; <italic>P</italic> = 0.047). The model also included the Acute Physiology and Chronic Health Evaluation II score, total Sequential Organ Failure Assessment on day 3, hepatic cirrhosis and medical admission.</p> </sec> <sec id="jep12137-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Within the limitations of a single‐centre approach, PU development appears to be associated with an increase in mortality among patients requiring MV for 24 hours or longer.</p> </sec> </abstract>