Genome‐wide association study identifies genomic regions of association for cruciate ligament rupture in Newfoundland dogs. (16th May 2014)

• Record Type: Journal Article
• Authors: Baird, A. E. G.; Carter, S. D.; Innes, J. F.; Ollier, W.; Short, A.
• Is Part Of: Animal genetics. Volume 45:Number 4(2014:Aug.)
• Page Start: 542
• Page End: 549
• Publication Date: 2014-05-16
• Subjects: Animal genetics -- Periodicals; 572.8
• DOI: 10.1111/age.12162
• Languages: English
• ISSNs: 0268-9146

Abstract

<abstract abstract-type="main" id="age12162-abs-0001"> <title>Summary</title> <p>Cranial cruciate ligament rupture (CCLR) is the most common cause of pelvic limb lameness in dogs. To investigate the genetic basis of canine CCLR, we conducted a genome‐wide association study using a canine SNP array in Newfoundland pedigree dogs with and without CCLR (<italic>n</italic> = 96). We identified three main chromosomal regions of CCLR association (on chromosomes 1, 3 and 33). Each of these regions was confirmed by Sequenom genotyping in a further cohort of Newfoundlands (<italic>n</italic> = 271). The results, particularly SNPs identified in the <italic>SORCS2</italic> and <italic>SEMA5B</italic> genes, suggest that there may be neurological pathways involved in susceptibility to canine CCLR.</p> </abstract>