Brain sections of hippocampus and fimbria area were obtained from 15‐week‐old ZrchI Prnp‐/‐ mice previously infected with 600 pfu/mouse of EMCV‐B on post‐infection day (DPI) 7. Sections used in the TUNEL method were counterstained with hematoxylin and eosin. CA1 pyramidal cells in the hippocampus of Rikn Prnp‐/‐ mice showed apoptosis. A brain section from Rikn Prnp‐/‐ mice shows mild mononuclear round cell infiltration. Modified from Fig. 3 in Nasu‐Nishimura et al. (2008) Arch Virol 153: 1007‐1012 with permission from Springer. (July 2014) - Onodera, Takashi; Sakudo, Akikazu; Tsubone, Hirokazu; Itohara, Shigeyoshi