Is microsatellite instability a prognostic marker in gastric cancer?: A systematic review with meta‐analysis. Issue 2 (15th April 2014)

• Record Type: Journal Article
• Authors: Choi, Yoon Young; Bae, Jung Min; An, Ji Yeong; Kwon, In Gyu; Cho, In; Shin, Hyun Beak; Eiji, Tanaka; Aburahmah, Mohammad; Kim, Hyung‐Il; Cheong, Jae‐Ho; Hyung, Woo Jin; Noh, Sung Hoon
• Is Part Of: Journal of surgical oncology. Volume 110:Issue 2(2014:Aug. 01)
• Page Start: 129
• Page End: 135
• Publication Date: 2014-04-15
• Subjects: Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.23618
• Languages: English
• ISSNs: 0022-4790

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jso23618-sec-0001" sec-type="section"> <title>Background and Objective</title> <p>The relationship between survival in gastric cancer patients and the status of microsatellite instability (MSI) has not yet been established. The purpose of this meta‐analysis was to obtain integrated and more precise data for the value of MSI as a prognostic marker in gastric cancer.</p> </sec> <sec id="jso23618-sec-0002" sec-type="section"> <title>Methods</title> <p>A comprehensive systematic review and meta‐analysis were conducted using major electronic databases (PubMed, EMBASE, and the Cochrane Central) with keywords related to "microsatellite instability, " "gastric cancer, " and "prognosis."</p> </sec> <sec id="jso23618-sec-0003" sec-type="section"> <title>Results</title> <p>Twenty‐four studies with 5, 438 participants (712 cases were MSI gastric cancer) were included for pooling risk estimates of MSI in gastric cancer. Seventeen studies reported overall survival. The pooled hazard ratio (HR) for overall survival of MSI vs. non‐MSI was 0.72 (95%CI: 0.59–0.88, <italic>P</italic> = .001) in a random‐effects model. In the sensitivity analysis, the result from the most recent study showed the most heterogeneity.</p> </sec> <sec id="jso23618-sec-0004" sec-type="section"> <title>Conclusion</title> <p>MSI gastric cancer was associated with good prognosis but there was heterogeneity in the recent studies. Changed epidemiology and effects of chemotherapy are potential causes of heterogeneity. Establishing a consensus for defining MSI in gastric cancer should be preferred for future studies. <italic>J. Surg. Oncol. 2014; 110:129–135</italic>. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>