Association of the c.385C>A (p.Pro129Thr) polymorphism of the fatty acid amide hydrolase gene with anorexia nervosa in the Japanese population. Issue 4 (24th February 2014)

• Record Type: Journal Article
• Authors: Ando, Tetsuya; Tamura, Naho; Mera, Takashi; Morita, Chihiro; Takei, Michiko; Nakamoto, Chiemi; Koide, Masanori; Hotta, Mari; Naruo, Tetsuro; Kawai, Keisuke; Nakahara, Toshihiro; Yamaguchi, Chikara; Nagata, Toshihiko; Ookuma, Kazuyoshi; Okamoto, Yuri; Yamanaka, Takao; Kiriike, Nobuo; Ichimaru, Yuhei; Ishikawa, Toshio; Komaki, Gen; The Japanese Genetic Research Group For Eating Disorders
• Is Part Of: Molecular genetics & genomic medicine. Volume 2:Issue 4(2014:Jul.)
• Page Start: 313
• Page End: 318
• Publication Date: 2014-02-24
• Subjects: Medical genetics -- Periodicals; Genomics -- Periodicals; 616.042
• DOI: 10.1002/mgg3.69
• Languages: English
• ISSNs: 2324-9269

Abstract

<abstract abstract-type="main" id="mgg369-abs-0001"> <title>Abstract</title> <p>The functional c.385C&gt;A single‐nucleotide polymorphism (SNP) in the fatty acid amide hydrolase (FAAH) gene, one of the major degrading enzymes of endocannabinoids, is reportedly associated with anorexia nervosa (AN). We genotyped the c.385C&gt;A SNP (rs324420) in 762 lifetime AN and 605 control participants in Japan. There were significant differences in the genotype and allele frequencies of c.385C&gt;A between the AN and control groups. The minor 385A allele was less frequent in the AN participants than in the controls (allele‐wise, odds ratio = 0.799, 95% confidence interval [CI] 0.653–0.976, <italic>P</italic> = 0.028). When the cases were subdivided into lifetime restricting subtype AN and AN with a history of binge eating or purging, only the restricting AN group exhibited a significant association (allele‐wise, odds ratio = 0.717, 95% CI 0.557–0.922, <italic>P</italic> = 0.0094). Our results suggest that having the minor 385A allele of the <italic>FAAH</italic> gene may be protective against AN, especially restricting AN. This finding supports the possible role of the endocannabinoid system in susceptibility to AN.</p> </abstract>