Chapter 2: Pathophysiology of neurogenic detrusor overactivity and the symptom complex of "Overactive bladder". Issue 3 (July 2014)

• Record Type: Journal Article
• Authors: Chapple, Christopher
• Is Part Of: Neurourology and urodynamics. Volume 33:Issue 3(2014:Mar.)
• Page Start: S6
• Page End: S13
• Publication Date: 2014-07
• Subjects: Urinary organs -- Periodicals; Urodynamics -- Periodicals; Urology -- Periodicals; 616.6
• DOI: 10.1002/nau.22635
• Languages: English
• ISSNs: 0733-2467

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="nau22635-sec-0001" sec-type="section"> <p>It is now clearly recognized that the function of the lower urinary tract represents a complex interaction between the bladder and its outlet, acting under the control of the central nervous system. While in the past attention has principally focused on the motor (efferent) control of the bladder, sensory (afferent) innervation is now known to be an important therapeutic target. This change in emphasis is strongly supported by both basic science and clinical evidence demonstrating the efficacy of therapy directed at the afferent system. This chapter summarizes the neurophysiological control mechanism that underpins normal lower urinary tract function, emphasizing the importance of the afferent system as a potential therapeutic target. <italic>Neurourol. Urodynam. 33:S6–S13, 2014</italic>. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>