Clinical significance of primary tumor resection in colorectal cancer patients with synchronous unresectable metastasis. Issue 2 (26th March 2014)

• Record Type: Journal Article
• Authors: Kim, Min Sung; Chung, MinKyu; Ahn, Joong Bae; Kim, Chang Woo; Cho, Min Soo; Shin, Sang Joon; Baek, Se Jin; Hur, Hyuk; Min, Byung Soh; Baik, Seung Hyuk; Kim, Nam Kyu
• Is Part Of: Journal of surgical oncology. Volume 110:Issue 2(2014:Aug. 01)
• Page Start: 214
• Page End: 221
• Publication Date: 2014-03-26
• Subjects: Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.23607
• Languages: English
• ISSNs: 0022-4790

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="jso23607-sec-0001" sec-type="section"> <title>Background</title> <p>The aim of this study was to compare the outcomes in colorectal cancer (CRC) patients with synchronous unresectable metastases who received either primary tumor resection (PTR) or chemotherapy as the first treatment and to investigate the clinical course of asymptomatic patients who received chemotherapy as the first treatment.</p> </sec> <sec id="jso23607-sec-0002" sec-type="section"> <title>Methods</title> <p>We retrospectively analyzed 324 CRC patients with synchronous unresectable metastases. Overall survival (OS) was analyzed for the two groups (upfront PTR group [n = 72] vs. upfront chemotherapy group [n = 252]). Surgical morbidity and mortality were recorded. In the asymptomatic patients who received upfront chemotherapy, the incidences of primary tumor‐related complications were analyzed.</p> </sec> <sec id="jso23607-sec-0003" sec-type="section"> <title>Results</title> <p>In patients who underwent PTR as the first treatment, the median OS period was superior to those who received upfront chemotherapy (17.2 vs. 13.6 months, <italic>P</italic> = 0.002). In the PTR group, surgical morbidity and mortality were 11.6% and 1.9%, respectively. Of the 252 asymptomatic patients, the incidence of primary tumor‐related complications was 35%. Emergent surgery was ultimately done in 14% of the 252 patients.</p> </sec> <sec id="jso23607-sec-0004" sec-type="section"> <title>Conclusion</title> <p>CRC patients with synchronous unresectable metastases who underwent PTR followed by chemotherapy had significantly longer survival times compared to patients who received chemotherapy as the first treatment. <italic>J. Surg. Oncol. 2014; 110:214–221</italic>. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>