Genetic variants in the IL1A gene region contribute to intestinal‐type gastric carcinoma susceptibility in European populations. Issue 6 (4th March 2014)

• Record Type: Journal Article
• Authors: Durães, Cecília; Muñoz, Xavier; Bonet, Catalina; García, Nadia; Venceslá, Adoración; Carneiro, Fátima; Peleteiro, Bárbara; Lunet, Nuno; Barros, Henrique; Lindkvist, Björn; Boutron‐Ruault, Marie‐Christine; Bueno‐de‐Mesquita, H. B(as); Rizzato, Cosmeri; Trichopoulou, Antonia; Weiderpass, Elisabete; Naccarati, Allessio; Travis, Ruth C.; Tjønneland, Anne; Gurrea, Aurelio Barricarte; Johansson, Mattias; Riboli, Elio; Figueiredo, Céu; González, Carlos Alberto; Capellà, Gabriel; Machado, José Carlos; Sala, Núria
• Is Part Of: International journal of cancer. Volume 135:Issue 6(2014:Sep. 15)
• Page Start: 1343
• Page End: 1355
• Publication Date: 2014-03-04
• Subjects: Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.28776
• Languages: English
• ISSNs: 0020-7136

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The most studied genetic susceptibility factors involved in gastric carcinoma (GC) risk are polymorphisms in the inflammation‐linked genes interleukin 1 (<italic>IL1</italic>) <italic>B</italic> and <italic>IL1RN</italic>. Despite the evidence pointing to the <italic>IL1</italic> region, definite functional variants reproducible across populations of different genetic background have not been discovered so far. A high density linkage disequilibrium (LD) map of the <italic>IL1</italic> gene cluster was established using HapMap to identify haplotype tagSNPs. Eighty‐seven SNPs were genotyped in a Portuguese case‐control study (358 cases, 1, 485 controls) for the discovery analysis. A replication study, including a subset of those tagSNPs (43), was performed in an independent analysis (EPIC‐EurGast) containing individuals from 10 European countries (365 cases, 1284 controls). Single SNP and haplotype block associations were determined for GC overall and anatomopathological subtypes. The most robust association was observed for SNP rs17042407, 16Kb upstream of the <italic>IL1A</italic> gene. Although several other SNP associations were observed, only the inverse association of rs17042407 allele C with GC of the intestinal type was observed in both studies, retaining significance after multiple testing correction (<italic>p</italic> = 0.0042) in the combined analysis. The haplotype analysis of the <italic>IL1A</italic> LD block in the combined dataset revealed the association between a common haplotype carrying the rs17042407 variant and GC, particularly of the intestinal type (<italic>p</italic> = 3.1 × 10<sup>−5</sup>) and non cardia localisation (<italic>p</italic> = 4.6 × 10<sup>−3</sup>). These results confirm the association of <italic>IL1</italic> gene variants with GC and reveal a novel SNP and haplotypes in the <italic>IL1A</italic> region associated with intestinal type GC in European populations.</p> </abstract>