Genes involved in neuroplasticity and stressful life events act on the short‐term response to antidepressant treatment: a complex interplay between genetics and environment. (20th May 2014)

• Record Type: Journal Article
• Authors: Mandelli, Laura; Emiliani, Roberta; Porcelli, Stefano; Fabbri, Chiara; Albani, Diego; Serretti, Alessandro
• Is Part Of: Human psychopharmacology. Volume 29:Number 4(2014:Jun.)
• Page Start: 388
• Page End: 391
• Publication Date: 2014-05-20
• Subjects: Psychopharmacology -- Periodicals; Psychotropic drugs -- Periodicals; Psychopharmacology -- Periodicals; Psychotropic Drugs -- pharmacology -- Periodicals; 615.78
• DOI: 10.1002/hup.2411
• Languages: English
• ISSNs: 0885-6222

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="hup2411-sec-0001" sec-type="section"> <title>Objective</title> <p>During the last few years, an increasing number of studies have focused on the association between neuroplasticity and affective disorders. The aim of the study is to evaluate the interactive effect of stressful life events (SLEs) and genes involved in neuroplasticity (BDNF and ST8SIA) on the short‐term response to antidepressant treatment.</p> </sec> <sec id="hup2411-sec-0002" sec-type="section"> <title>Methods</title> <p>A total of 114 patients affected by mood or anxiety disorders under antidepressant treatment were enrolled in the study. We evaluated the interactive effects of three BDNF single‐nucleotide polymorphisms (SNPs) and five ST8SIA SNPs and SLEs at different time points (childhood SLEs, SLEs at illness onset, and SLEs reported over the last preceding treatment) over 1‐month of antidepressant treatment.</p> </sec> <sec id="hup2411-sec-0003" sec-type="section"> <title>Results</title> <p>Carriers of some genetic variants in both BDNF and ST8SIA had a slower response to antidepressants if non‐exposed to the onset SLEs, whereas they had a similar trend compared with the carriers of the opposite variant if exposed (allelic analysis: BDNF <italic>p</italic> = 0.00003, <italic>p</italic> = 0.00609; ST8SIA <italic>p</italic> = 0.04, <italic>p</italic> = 0.033). The BDNF haplotype analysis confirmed this trend (<italic>p</italic> = 0.00016).</p> </sec> <sec id="hup2411-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Though our results are limited by the small sample size, variants in BDNF and ST8SIA may slow down the early response to antidepressants in subjects non‐exposed to stressors at the illness onset, with a remarkable gene–environment interaction. Copyright © 2014 John Wiley & Sons, Ltd.</p> </sec> </abstract>