Reference range of fetal nasal bone length between 18 and 24 weeks of pregnancy in an unselected Brazilian population: experience from a single service. (August 2014)

• Record Type: Journal Article
• Authors: Araujo Júnior, Edward; Martins, Wellington P.; Pires, Claudio Rodrigues; Moron, Antonio Fernandes; Zanforlin Filho, Sebastião Marques
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 27:Number 12(2014:Dec.)
• Page Start: 1276
• Page End: 1279
• Publication Date: 2014-08
• Subjects: Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2013.852177
• Languages: English
• ISSNs: 1476-7058

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: To determine reference range of fetal nasal bone length (NBL) during the second trimester of pregnancy in a Brazilian population.</p> <p> <italic>Methods</italic>: This was a retrospective cross-sectional study with 2681 normal singleton pregnancies between 18 and 24 weeks of gestation. The NBL was obtained in the mid-sagittal plane of the fetal face profile using the following landmarks: nasal bone, overlying skin and the tip of the nose. The NBL was measured by placing the calipers in the out-to-out position. To assess the correlation between NBL and gestational age (GA), polynomial equations were calculated, with adjustments by coefficient of determination (<italic>R</italic>²).</p> <p> <italic>Results</italic>: The mean of NBL ranged from 5.72 ± 0.87 mm at 18–18 + 6 weeks to 7.45 ± 1.23 mm at 24–24+6 weeks of pregnancy. We observed a good correlation between NBL and GA, best represented by a linear equation: NBL = 0.080+0.276*GA (<italic>R</italic>²= 0.16).</p> <p> <italic>Conclusion</italic>: We established a reference range of fetal NBL in the second trimester of pregnancy in a Brazilian population.</p> </abstract>