Clinical features of Behcet's disease in patients without oral aphthosis. Issue 4 (July 2014)

• Record Type: Journal Article
• Authors: Faezi, Seyedeh Tahereh; Paragomi, Pedram; Shahram, Farhad; Shams, Hormoz; Shams-Davatchi, Cheida; Ghodsi, Zahra; Nadji, Abdolhadi; Akhlaghi, Maassoumeh; Davatchi, Fereydoun
• Is Part Of: Modern rheumatology. Volume 24:Issue 4(2014)
• Page Start: 637
• Page End: 639
• Publication Date: 2014-07
• Subjects: Rheumatology -- Periodicals; 616.723005
• DOI: 10.3109/14397595.2013.844400
• Languages: English
• ISSNs: 1439-7595

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objectives.</italic> In current study we evaluated clinical features of Behcet's Disease (BD) in patients without oral aphthosis (NOA cases).</p> <p> <italic>Methods.</italic> In a cohort of BD, patients registered during a period of 36 years were collected.</p> <p>We determined clinical features of BD NOA cases and compared them with patients with oral aphthosis (OA cases). The comparison was performed by chi square and Fischer's exact test.</p> <p> <italic>Results.</italic> Among 6821 BD patients, 175 patients (2.56%) were NOA cases. Male/Female ratio was less in NOA cases (p-value: 0.078). Mean age of disease onset was significantly higher in NOA cases (p-value: 0.001). Among NOA cases, the first manifestations comprised uveitis (70.3%), joint involvement (8.0%), retinal vasculitis (6.9%), and genital aphthosis (4.0%). During the course of disease, the prevalence of ocular lesions and positive pathergy test were significantly higher in NOA cases. Conversely genital aphthosis (OR: 0.048), mucocutaneous (OR: 0.470), joint involvement (OR: 0.478), and positive family history for BD (OR:0.138) were significantly less frequent in NOA cases. NOA cases fulfilled different criteria including International Criteria for BD (ICBD), Japan Revised, Iran, Dilsen, and Classification Tree.</p> <p> <italic>Conclusions.</italic> These results addressed the distinct clinical features in NOA subset of BD Including more prevalent eye involvement and positive pathergy.</p> </abstract>