A Meta-analysis of the Association between p53 Codon 72 Polymorphism and Susceptibility to Endometriosis. (August 2014)

• Record Type: Journal Article
• Authors: Song, Gwan Gyu; Lee, Young Ho
• Is Part Of: Immunological investigations. Volume 43:Number 6(2014)
• Page Start: 595
• Page End: 605
• Publication Date: 2014-08
• Subjects: Immunology -- Periodicals; Immunochemistry -- Periodicals; Cellular immunity -- Periodicals; Communicable diseases -- Periodicals; 616.079
• DOI: 10.3109/08820139.2013.833623
• Languages: English
• ISSNs: 0882-0139

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Objective</italic>: The aim of this study was to determine whether the p53 codon 72 polymorphism is associated with susceptibility to endometriosis.</p> <p> <italic>Methods</italic>: A meta-analysis was conducted on the associations between the p53 codon 72 polymorphism and endometriosis using 1) allele contrast, 2) a recessive model, 3) a dominant model, and 4) homozygote contrast.</p> <p> <italic>Results</italic>: Nine studies involving 1, 803 patients and 2, 006 controls were considered in the meta-analysis. Meta-analysis of the p53 polymorphism showed no association between endometriosis and the p53 C allele (odds ratio (OR) = 1.087, 95% confidence interval (CI) = 0.921–1.282, <italic>p</italic> = 0.323). Stratification by ethnicity indicated no association between the p53 C allele and endometriosis in Europeans and Latin Americans. However, a significant association was found between the p53 C allele and endometriosis in East Asians (OR = 1.405, 95% CI = 1.065–1.854, <italic>p</italic> = 0.016). Furthermore, association was found between the p53 polymorphism and endometriosis in East Asians using the dominant model (OR = 2.046, 95% CI = 1.123–3.730, <italic>p</italic> = 0.019).</p> <p> <italic>Conclusions:</italic> This meta-analysis demonstrates that the p53 codon 72 polymorphism may be associated with susceptibility to endometriosis in East Asians, but not in Europeans and Latin Americans.</p> </abstract>