Sexual Dysfunction Induced by Intrathecal Baclofen Administration: Is This the Price to Pay for Severe Spasticity Management?. (9th May 2014)

• Record Type: Journal Article
• Authors: Calabrò, Rocco Salvatore; D'Aleo, Giangaetano; Sessa, Edoardo; Leo, Antonino; De Cola, Maria Cristina; Bramanti, Placido
• Is Part Of: Journal of sexual medicine. Volume 11:Number 7(2014:Jul.)
• Page Start: 1807
• Page End: 1815
• Publication Date: 2014-05-09
• Subjects: Sexual disorders -- Periodicals; Sex -- Periodicals; Sexual health -- Periodicals; 616.69005
• DOI: 10.1111/jsm.12569
• Languages: English
• ISSNs: 1743-6095

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jsm12569-sec-0001" sec-type="section"> <title>Introduction</title> <p>Intrathecal administration of baclofen (ITB) is widely recognized as an effective treatment for severe spasticity of both spinal and supraspinal origin with fewer side effects. The lower drug dosages used for spinal intrathecal administration, acting directly on the receptor sites, result in greater therapeutic efficacy with less systemic toxicity than with oral preparations.</p> </sec> <sec id="jsm12569-sec-0002" sec-type="section"> <title>Aim</title> <p>This study aims to prospectively evaluate the effects of ITB on erectile function in male patients affected by severe spasticity.</p> </sec> <sec id="jsm12569-sec-0003" sec-type="section"> <title>Methods</title> <p>Twenty adult male patients, with a 34.85 ± 10.27 mean age, affected by severe spasticity mainly due to spinal cord lesions (10 traumatic, three vascular, six degenerative, and one congenital in origin) and treated with ITB, were enrolled in the study. All participants underwent specific clinical scales to evaluate force, muscle tone, cognition and mood, and specific sexual questionnaires, including an accurate semi‐structured interview.</p> </sec> <sec id="jsm12569-sec-0004" sec-type="section"> <title>Main Outcome Measure</title> <p>The International Index of Erectile Function (IIEF) was used to evaluate sexual function before and after pump implantation.</p> </sec> <sec id="jsm12569-sec-0005" sec-type="section"> <title>Results</title> <p>A comparative analysis of the neurological scales and psychometric scores at T1 (baseline) and T2 (follow‐up) showed statistically significant differences before and after pump implantation. In particular, we noted a significant decrease in the IIEF median scores (from 0.42 ± 0.07 to 0.14 ± 0.02, <italic>P</italic> value < 0.0001) and a correlation between ITB dosage and IIEF scores (ρ = −0.60; <italic>P</italic> < 0.05).</p> </sec> <sec id="jsm12569-sec-0006" sec-type="section"> <title>Conclusions</title> <p>This study supports previous findings on a possible negative effect of ITB on sexual function, with regard to erection. Patients who are considering ITB for treatment of severe spasticity should be informed about possible but reversible sexual side effects, especially at higher dosage. Future studies with larger samples should be fostered to confirm these findings for a better management of these, often young, patients. <bold>Calabrò RS, D'Aleo G, Sessa E, Leo A, De Cola MC, and Bramanti P. Sexual dysfunction induced by intrathecal baclofen administration: Is this the price to pay for severe spasticity management? J Sex Med 2014;11:1807–1815.</bold></p> </sec> </abstract>