C‐Reactive Protein, Vitamin D Deficiency, and Slow Gait Speed. Issue 9 (8th August 2013)

• Record Type: Journal Article
• Authors: Kositsawat, Jatupol; Barry, Lisa C.; Kuchel, George A.
• Is Part Of: Journal of the American Geriatrics Society. Volume 61:Issue 9(2013:Sep.)
• Page Start: 1574
• Page End: 1579
• Publication Date: 2013-08-08
• Subjects: Geriatrics -- Periodicals; 618.97
• DOI: 10.1111/jgs.12403
• Languages: English
• ISSNs: 0002-8614

Abstract

<abstract abstract-type="main" id="jgs12403-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jgs12403-sec-0001" sec-type="section"> <title>Objectives</title> <p>To evaluate the independent and joint effects of C‐reactive protein (CRP) and 25‐OH vitamin D (25(OH)D) levels on mobility disability in older persons.</p> </sec> <sec id="jgs12403-sec-0002" sec-type="section"> <title>Design</title> <p>U.S. population‐based cross‐sectional study.</p> </sec> <sec id="jgs12403-sec-0003" sec-type="section"> <title>Setting</title> <p>National Health and Nutrition Examination Surveys (2001–2002).</p> </sec> <sec id="jgs12403-sec-0004" sec-type="section"> <title>Participants</title> <p>Individuals aged 50 and older (N = 1, 826).</p> </sec> <sec id="jgs12403-sec-0005" sec-type="section"> <title>Measurements</title> <p>C‐reactive protein (mg/dL), with high CRP defined as ≥0.2 mg/dL, and 25(OH)D levels (ng/mL) operationalized as severe deficiency (<10 ng/mL), deficiency (10–19.9 ng/mL), insufficiency (20–29.9 ng/mL), and normal (≥30 ng/mL). Mobility disability was operationalized as gait speed of <0.8 m/s while completing a 20‐foot walk (6.1 m).</p> </sec> <sec id="jgs12403-sec-0006" sec-type="section"> <title>Results</title> <p>High CRP and low 25(OH)D levels were associated with slow gait speed. Individuals with high CRP levels and severe vitamin D deficiency were more likely to have slow gait speed than were those with neither risk factor (odds ratio = 3.54, 95% confidence interval = 1.42–8.84, <italic>P</italic> = .007). A significant positive association between vitamin D level and gait speed was found only in those with high CRP in stratified analyses. Whites and blacks showed similar findings as the overall population.</p> </sec> <sec id="jgs12403-sec-0007" sec-type="section"> <title>Conclusion</title> <p>These findings provide evidence of a potential joint effect of vitamin D and CRP on gait speed, suggesting that evaluation and correction of vitamin D levels may be especially important in individuals with high CRP levels.</p> </sec> </abstract>