Use of the continuous glucose monitoring system to treat insulin autoimmune syndrome: quantification of glucose excursions and evaluation of treatment efficacy. Issue 7 (July 2014)

• Record Type: Journal Article
• Authors: Philippon, M.; Séjil, S.; Mugnier, M.; Rocher, L.; Guibergia, C.; Vialettes, B.; Delenne, B.
• Is Part Of: Diabetic medicine. Volume 31:Issue 7(2014:Jul.)
• Page Start: e20
• Page End: e24
• Publication Date: 2014-07
• Subjects: Diabetes -- Periodicals; 616.462
• DOI: 10.1111/dme.12418
• Languages: English
• ISSNs: 0742-3071

Abstract

<abstract abstract-type="main" id="dme12418-abs-0001"> <title>Abstract</title> <sec id="dme12418-sec-0001" sec-type="section"> <title>Background</title> <p>Autoimmune hypoglycaemia, based on the presence of autoantibodies directed against endogenous insulin (insulin autoimmune syndrome or Hirata's disease), is a rare cause of hypoglycaemia. Treatment of the disease is not standardized and various therapeutic options have been proposed. We wondered whether using a continuous glucose‐monitoring system could help quantify precisely glucose excursions and allow evaluation of treatment efficacy.</p> </sec> <sec id="dme12418-sec-0002" sec-type="section"> <title>Case report</title> <p>A 44‐year‐old Caucasian patient with insulin autoimmune syndrome was studied for 7 days using a continuous glucose monitoring system under various treatment regimens, i.e. diet modification, high‐dose corticosteroids, alpha‐glucosidase inhibitors, and plasmapheresis.</p> </sec> <sec id="dme12418-sec-0003" sec-type="section"> <title>Conclusion</title> <p>Continuous glucose monitoring system data confirmed that insulin autoimmune syndrome alternated between periods of prandial hyperglycaemia and interprandial hypoglycaemia. Alpha glucosidase inhibitors and plasmapheresis were more potent in limiting glucose excursions than corticosteroid or diet‐only treatments. The continuous glucose monitoring system appears to be a useful tool in the management of insulin autoimmune syndrome.</p> </sec> </abstract>